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Name (+)-Camptothecin
CAS 7689-03-4
EINECS(EC#) 444-280-6
Molecular Formula C20H16N2O4
MDL Number MFCD00081076
Molecular Weight 348.35
MOL File 7689-03-4.mol

Chemical Properties

Appearance light yellow crystal powde
Melting point  260 °C (dec.)(lit.)
alpha  D25 +31.3° (in chloroform-methanol, 8:2)
Boiling point  482.73°C (rough estimate)
density  1.3112 (rough estimate)
refractive index  1.5700 (estimate)
storage temp.  2-8°C
solubility  chloroform/methanol (4:1): 4 mg/mL
form  solid
pka pKa 10.83 (Uncertain)
color  yellow
Water Solubility  insoluble
Usage Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent
Detection Methods HPLC
Merck  1735
BRN  631069
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
LogP 1.740
CAS DataBase Reference 7689-03-4(CAS DataBase Reference)

Safety Data

Hazard Codes  T,Xi,Xn
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
R25:Toxic if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Statements 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS  UQ0492000
Hazard Note  Irritant
HazardClass  6.1
HS Code  29399900

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