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AG 490

AG 490 Structure
AG 490
  • CAS No.133550-30-8
  • Chemical Name:AG 490
  • CBNumber:CB4779212
  • Molecular Formula:C17H14N2O3
  • Formula Weight:294.3
  • MOL File:133550-30-8.mol
AG 490 Property
  • Melting point 215°C(lit.)
  • Boiling point 615.2±55.0 °C(Predicted)
  • Density 1.337
  • storage temp. -20°C
  • solubility ethanol: 5 mg/mL
  • form solid
  • pka 8.75±0.10(Predicted)
  • color yellow
  • biological source synthetic (organic)
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.
  • InChIKey TUCIOBMMDDOEMM-ZSOIEALJSA-N
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :Xi,N,T
  • Risk Statements  :36/37/38-50-25
  • Safety Statements  :26-36-61-45
  • RIDADR  :UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
  • WGK Germany  :1
  • RTECS  :UC6316197
  • HazardClass  :6.1
  • PackingGroup  :III
  • HS Code  :29269090
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301-H400
  • Precautionary statements P273-P301+P310
AG 490 Price More Price(6)
  • Brand: Sigma-Aldrich(India)
  • Product number: T3434
  • Product name : Tyrphostin AG 490
  • Purity: solid
  • Packaging: 5MG
  • Price: ₹10640.98
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T3434
  • Product name : Tyrphostin AG 490
  • Purity: solid
  • Packaging: 25MG
  • Price: ₹43126.8
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 658401
  • Product name : AG 490 - CAS 133550-30-8 - Calbiochem
  • Purity: A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC?? = 100 n
  • Packaging: 5MG
  • Price: ₹5880
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: T2962
  • Product name : Tyrphostin AG 490
  • Purity: 
  • Packaging: 20MG
  • Price: ₹3800
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: T2962
  • Product name : Tyrphostin AG 490
  • Purity: 
  • Packaging: 100MG
  • Price: ₹8800
  • Updated: 2022/05/26
  • Buy: Buy

AG 490 Chemical Properties,Usage,Production

  • Description AG-490 (133550-30-8) is a potent inhibitor of the JAK2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock.3 AG-490 is a useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes.4
  • Uses AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8 μM for EGFR and JAK, respectively.
  • Uses Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity5. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells6.
  • Definition ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.
  • Biological Activity Selective inhibitor of EGF receptor tyrosine kinase (IC 50 values are 2 and 13.5 μ M for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo .
  • Biochem/physiol Actions Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.
  • storage Room temperature
  • References References/Citations 1) Wang et al. (1999), JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response; J. Immunol. 162 3897 2) Meydan et al. (1996), Inhibition of acute lymphoblastic leukaemia by Jak-2 inhibitor; Nature, 379 645 3) Gyurkovska and Ivanovaska (2015), Tyrosine kinase inhibitor tyrphostin AG490 reduces liver injury in LPS-induced shock; Eur. J. Pharmacol., 751 118 4) Wu et al. (2015), ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca(+2) overload and contractile dysfunction via the JAK2/STAT3 pathway; J. Mol. Cell. Cardiol., 81 150
AG 490 Preparation Products And Raw materials
Raw materials
Preparation Products
AG 490 Suppliers
Global(176)Suppliers
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    Henan Tianfu Chemical Co.,Ltd.
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AG 490 Spectrum
133550-30-8, AG 490Related Search:
  • Protein Kinase
  • Inhibitor
  • Inhibitors
  • Intracellular Signaling
  • 抑制剂
  • 生化试剂
  • 生物试剂
  • 原料药
  • 小分子抑制剂，天然产物
  • 蛋白酪氨酸激酶
  • 小分子抑制剂
  • Janus Kinase (JAK)
  • Kinase/Phosphatase Biology
  • Non-Receptor Tyrosine Kinase Inhibitors
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • AG 490(TYRPHOSTIN AG 490,TYRPHOSTIN B42) |CAS 133550-30-8
  • 酪氨酸激酶抑制剂AG 490
  • 化合物AG-490,10 MM DMSO 溶液
  • AG 490,JAK2/3抑制剂
  • (E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺
  • 化合物AG-490
  • 酪磷蛋白 AG 490
  • AG-490, 一种EGFR抑制剂
  • 133550-30-8
  • AG490, 10 mM in DMSO
  • AG 490, JAK2/3 inhibitor
  • AG 49
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  • Tyrphostin AG490 AG-490 JAK-2 specific inhibitor
  • Tyrphostin B42 (AG-490)
  • AG 490 - CAS 133550-30-8 - Calbiochem
  • CS-316
  • AG 490;TYRPHOSTIN AG 490;AG490;ZINC02557947;AG-490 (TYRPHOSTIN B42)
  • TIANFU-CHEM AG 490
  • zinc0255794)
  • AG490(Tyrphostin )
  • 0 Tyrphostin AG 490
  • AG-490, 99%, an inhibitor of EGFR
  • ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE
  • AG 490
  • A-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE
  • A-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMAMIDE
  • (E)-2-CYANO-3-(3,4-DIHYDROPHENYL)-N-(PHENYLMETHYL)-2-PROPENAMIDE
  • 2-PropenaMide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylMethyl)-, (2E)-
  • AG 490(Tyrphostin AG 490,Tyrphostin B42)
  • (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
  • (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
  • N-Benzyl-2-cyano-3-(3,4-dihydroxy-phenyl)-acrylamide
  • AG 490 (Tyrphostin AG 490)
  • bis-tyrphostin B42
  • 2-cyano-3-(3,4-dihydroxyphenyl)-n-(benzyl)-2-propenamide
  • TYRPHOSTIN B42
  • TYRPHOSTIN AG 490
  • TYROPHOSTIN AG490
  • N-BENZYL-3,4-DIHYDROXY-BENZYLIDENECYANOACETAMIDE
  • N-BENZYL-3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE

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