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TYRPHOSTIN B48

TYRPHOSTIN B48 Structure
TYRPHOSTIN B48
  • CAS No.133550-35-3
  • Chemical Name:TYRPHOSTIN B48
  • CBNumber:CB9319132
  • Molecular Formula:C16H12N2O3
  • Formula Weight:280.28
  • MOL File:133550-35-3.mol
TYRPHOSTIN B48 Property
  • Melting point 249 °C(dec.)
  • storage temp. Keep in dark place,Sealed in dry,2-8°C
  • solubility DMSO: soluble
  • form Yellow solid.
  • color Light yellow to Amber to Dark green
Safety
  • Safety Statements  :22-24/25
  • RIDADR  :3439
  • WGK Germany  :3
  • HS Code  :2926.90.4801
  • HazardClass  :6.1
  • PackingGroup  :III
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301-H315-H319
  • Precautionary statements P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501
TYRPHOSTIN B48 Price More Price(2)
  • Brand: TCI Chemicals (India)
  • Product number: A2704
  • Product name : Tyrphostin AG 494
  • Purity: 
  • Packaging: 20MG
  • Price: ₹5900
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: A2704
  • Product name : Tyrphostin AG 494
  • Purity: 
  • Packaging: 100MG
  • Price: ₹10500
  • Updated: 2022/05/26
  • Buy: Buy

TYRPHOSTIN B48 Chemical Properties,Usage,Production

  • Description Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells.
  • Uses AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3].
  • Biological Activity Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively).
  • IC 50 EGFR: 0.7 μM (IC50)
  • References [1]. osherov n, levitzki a. tyrphostin ag 494 blocks cdk2 activation. febs lett, 1997, 410(2-3): 187-190.
    [2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
    [3]. liu x, qin j, luo q, et al. cross-talk between egf and bmp9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. j cell mol med, 2013, 17(9): 1160-1172.
    [4]. bojko a1, reichert k, adamczyk a, et al. the effect of tyrphostins ag494 and ag1478 on the autocrine growth regulation of a549 and du145 cells. folia histochem cytobiol, 2012, 50(2): 186-195.
TYRPHOSTIN B48 Preparation Products And Raw materials
Raw materials
Preparation Products
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TYRPHOSTIN B48 Spectrum
133550-35-3, TYRPHOSTIN B48Related Search:
  • Intracellular Signaling
  • API
  • Protein Kinase
  • 抑制剂
  • 生化试剂
  • 活性氧
  • 芳烃
  • Epidermal Growth Factor Receptor (EGFR)
  • Kinase/Phosphatase Biology
  • Receptor Tyrosine Kinase Inhibitors
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • AG-494 |CAS 133550-35-3
  • 化合物AG 494,10 MM DMSO 溶液
  • AG-494,EGF RECEPTOR TYROSINE KINASE
  • (E)-2-氰基-3-(3,4-二羟基苯基)-N-苯基-2-丙烯酰胺
  • (E)-2-氰基-3-(3,4-二羟基苯基)-N-苯基丙烯酰胺
  • 化合物AG 494
  • (2E)-2-氰基-3-(3,4-二羟基苯基)-N-苯基-2-丙烯酰胺
  • 酪氨酸激酶抑制剂 AG 494
  • 133550-35-3
  • AG-494, 10 mM in DMSO
  • AG-494, EGF receptor tyrosine kinase
  • A -494
  • DNA,ErbB-1,differentiation,Epidermal growth factor receptor,Cyclin dependent kinase,EGFR,HER1,Inhibitor,CDK,autophosphorylation,osteogenic,synthesis,Tyrphostin AG494,Tyrphostin AG 494,AG-494,activation,inhibit,Cdk2,AG494
  • AG-494 Tyrphostin
  • -494 Tyrphostin
  • 494
  • 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-, (2E)-
  • TyrphostinAG494&gt
  • CS-2755
  • AG-494;AG 494;AG494
  • -2-Cyano-3-(3,4-dihydroxyphenyl)
  • (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide
  • (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-phenyl-2-propenamide
  • AG 494 (Tyrphostin AG 494)
  • N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B48
  • TYRPHOSTIN AG 494
  • TYRPHOSTIN B48
  • N-PHENYL-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE
  • AG 494
  • A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE
  • A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE
  • ALPHA-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE
  • (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE

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