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o-Dianisidine

CAS No.119-90-4
Chemical Name:o-Dianisidine
CBNumber:CB7385595
Molecular Formula:C14H16N2O2
Formula Weight:244.29
MOL File:119-90-4.mol

o-Dianisidine Property

Melting point 137-138 °C(lit.)
Boiling point 387.21°C (rough estimate)
Density 1.1079 (rough estimate)
refractive index 1.6000 (estimate)
Flash point 403 °F
storage temp. Store at RT.
solubility H₂O: slightly soluble
pka 4.71±0.10(Predicted)
Colour Index 37235
form Crystalline Powder
color Pink to beige-brown
Water Solubility Soluble in alcohol, benzene, ether, chloroform, acetone, most organic solvents and lipids. Slightly soluble in water.
Merck 14,2991
BRN 1879884
CAS DataBase Reference 119-90-4(CAS DataBase Reference)
EWG's Food Scores 5
FDA UNII MJY508JZXV
Proposition 65 List 3,3'-Dimethoxybenzidine (o-Dianisidine)
IARC 2B (Vol. 4, Sup 7) 1987
NIST Chemistry Reference Benzidine, 3,3'-dimethoxy-(119-90-4)
EPA Substance Registry System 3,3'-Dimethoxybenzidine (119-90-4)
UNSPSC Code 41116105
NACRES NA.83

Safety

Hazard Codes :T
Risk Statements :45-22
Safety Statements :53-45
RIDADR :2811
WGK Germany :3
RTECS :DD0875000
TSCA :Yes
HazardClass :6.1(a)
PackingGroup :II
HS Code :29222990
Hazardous Substances Data :119-90-4(Hazardous Substances Data)
Toxicity :Dianisidine is a probable carcinogen used in the manufacture of dyes. EPA has classified as a Group 2B—probable human carcinogen.

NFPA 704:

	1
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H350
Precautionary statements P201-P301+P312+P330-P308+P313

o-Dianisidine Price More Price(16)

Brand: Sigma-Aldrich(India)
Product number: D9143
Product name : o-Dianisidine
Purity: peroxidase substrate
Packaging: 5G
Price: ₹3344.93
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: D9143
Product name : o-Dianisidine
Purity: peroxidase substrate
Packaging: 25G
Price: ₹12957.53
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 33430
Product name : o-Dianisidine
Purity: for spectrophotometric det. of Au, NO2-, Ce(IV), for the detection of Au, Co, Cu, SCN-, V, ≥97.0%
Packaging: 10G
Price: ₹11128.1
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 33430
Product name : o-Dianisidine
Purity: for spectrophotometric det. of Au, NO2-, Ce(IV), for the detection of Au, Co, Cu, SCN-, V, ≥97.0%
Packaging: 50G
Price: ₹20567.5
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: D3864
Product name : o-Dianisidine [for Biochemical Research]
Purity:
Packaging: 1G
Price: ₹2200
Updated: 2022/05/26
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o-Dianisidine Chemical Properties,Usage,Production

Description DMOB is a colorless crystalline materialwhich may turn purple on standing in air. Molecularweight=244.32; Freezing/Melting point=137-138℃;Flash point=206℃. Hazard Identification (based onNFPA-704 M Rating System): Health 2, Flammability 1,Reactivity 0. Slightly soluble in water.
Chemical Properties o-Dianisidine, crystallizes dimorphically, rarely in needles, with mp 133°C , often in flakes with mp 137-138°C . It forms colorless crystals, but commercial products have a tinge of violet. It is sparingly soluble in water but soluble in alcohol, ether, and benzene. One gram of ethyl acetate dissolves 0.285 g of o-dianisidine at 73°C .

The pure compound is stable upon exposure to air, but commercial products turn violet. o-Dianisidine is resistant to water but sensitive to oxidizing agents.
Uses o-Dianisidine is a starting material for the production of disazo dyes and pigments.
Like benzidine and o-tolidine, o-dianisidine forms colors with numerous oxidizing agents, e.g., copper, cobalt, and gold ions. o-Dianisidine is quantitatively determined by titration with nitrite using potassium iodide and starch paper as the indicator. o-Dianisidine can be detected in the urine using potassium 1,2-naphthoquinone4-sulfonate after extraction. A rapid and easy method is based on the color formed with cyanogen bromide. Its detection limit is 0.05 mg/kg.
The free o-dianisidine base and the dihydrochloride are marketed in moist forms with a 10-30% water content.
Uses o-Dianisidine is used as a redox indicator. It is used as an intermediate for the preparation of azo dyes, pigments and o-dianisidine diisocyanate, which finds application in adhesives, polyurethane elastomers and resins. It is also used in various industries like leather, paper, plastics, rubber, and textiles. It acts as a reagent to detect metals, thiocyanates, and nitrites.
Uses o-Dianisidine is used almost exclusively as a chemical intermediate for producing dyes and pigments. In 1971, the Society of Dyers and Colourists reported its use in the production of 89 dyes (see Dyes Metabolized to o-Dianisidine, below). o-Dianisidine is also used as a chemical intermediate to produce o-dianisidine diisocyanate for use in adhesives and as a component of polyurethanes. Other uses are as a dye for paper, plastics, rubber, and textiles and as a test substance for detection of metals, thiocyanates, and nitrites (IARC 1974, HSDB 2009).
Preparation 2-Nitroanisole is reduced (H2-catalyst or iron-formic acid) to o-anisidine or (benzidine-type reaction) to o-dianisidine [119-90-4], both of which are important as dye intermediates.
Definition ChEBI: 3,3'-Dimethoxybenzidine is a member of biphenyls.
Synthesis Reference(s) Journal of the American Chemical Society, 106, p. 7077, 1984 DOI: 10.1021/ja00335a035
General Description Colorless crystals or a light brown powder. Turns violet on standing. Carcinogen.
Air & Water Reactions Finely powdered material is a significant dust explosion hazard. Insoluble in water.
Reactivity Profile o-Dianisidine is a weak base. Reacts exothermically with acids. Sensitive to heat, air and prolonged exposure to light.
Fire Hazard o-Dianisidine is combustible.
Safety Profile Confirmed carcinogen with experimental tumorigenic data. Moderately toxic by ingestion. Mutation data reported. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx.
Toxicology In the presence of rat liver homogenate, o- dianisidine is positive in the Ames test. It is capable of inducing unscheduled DNA synthesis inHeLa cells and in primary rat hepatocytes, and it provokes cell transformation in baby hamster kidney cells in vitro. o-Dianisidine is carcinogenic in rats. An oral dose of 30 mg administered three times per week for 13 months produced tumors in the zymbal glands and in other tissues. No conclusive epidemiological studies have been reported on the carcinogenicity of o-diani- sidine in humans. No MAK value has been established. o-Dianisidine is classified in group III B.
Potential Exposure Tumorigen,Mutagen; Human Data. DMOB or its dihydrochloride isused principally as a chemical intermediate for the production of azo dyes. About 30% of DMOB is used as a chemical intermediate in the production of o-dianisidinediisocyanate (3,30-dimethoxy-4,40-diisocyanate-biphenyl)that is used in adhesive systems and also as a component ofpolyurethane elastomers and resins. DMOB is used as a dyeitself for leather, paper, plastics, rubber, and textiles.DMOB has also been used in the detection of metals, thiocyanates, and nitrites.
First aid If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Carcinogenicity o-Dianisidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
storage Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. 3,30-Dimethoxybenzidine mayreact with oxidizers (such as perchlorates, peroxides, permanganates, chlorates, and nitrates). Store in tightly closedcontainers in a cool, well-ventilated area. Avoid exposureto light. A regulated, marked area should be establishedwhere this chemical is handled, used, or stored in compliance with OSHA Standard 1910.1045.
Shipping Dyes, liquid, toxic, n.o.s or Dye intermediates,liquid, toxic, n.o.s. require a label of “POISONOUS/TOXICMATERIALS.” They fall in Hazard Class 6.1 and 3,30-dimethoxybenzidine in Packing Group II.

Properties and Applications red light navy blue light to dark. And C.I.Azoic Diazo Component 48 the same chemical structure.

Standard(Polyamide)	Ironing Fastness		Light Fastness	Persperation Fastness		Washing Fastness
Standard(Polyamide)	Fading	Stain	Light Fastness	Fading	Stain	Fading	Stain
AATCC			2	5	5	5	5

Incompatibilities Oxidizers.
Toxics Screening Level The initial threshold screening level (ITSL) for 3,3’-dimethoxybenzidine (CAS# 119-90-4) is 9.8 μg/m3 based on an annual averaging time.