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2-Nitroanisole

2-Nitroanisole Structure
2-Nitroanisole
  • CAS No.91-23-6
  • Chemical Name:2-Nitroanisole
  • CBNumber:CB1101492
  • Molecular Formula:C7H7NO3
  • Formula Weight:153.14
  • MOL File:91-23-6.mol
2-Nitroanisole Property
  • Melting point 9-12 °C (lit.)
  • Boiling point 273 °C (lit.)
  • Density 1.254 g/mL at 25 °C (lit.)
  • refractive index n20/D 1.561(lit.)
  • Flash point >230 °F
  • storage temp. Refrigerator, Under Inert Atmosphere
  • solubility alcohol: soluble(lit.)
  • form Oil
  • color Pale Yellow
  • Specific Gravity 1.254
  • Water Solubility 1.45 g/L (20 ºC)
  • Merck 14,6584
  • BRN 1868032
  • Dielectric constant 43.0
  • Stability Stable. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference 91-23-6(CAS DataBase Reference)
  • EWG's Food Scores 3
  • FDA UNII ZRE7HLZ17K
  • Proposition 65 List o-Nitroanisole
  • NIST Chemistry Reference Benzene, 1-methoxy-2-nitro-(91-23-6)
  • IARC 2A (Vol. 65, 127)
  • EPA Substance Registry System o-Nitroanisole (91-23-6)
  • UNSPSC Code 12352100
  • NACRES NA.22
Safety
  • Hazard Codes  :T
  • Risk Statements  :45-22
  • Safety Statements  :53-45
  • RIDADR  :UN 2730 6.1/PG 3
  • WGK Germany  :3
  • RTECS  :BZ8790000
  • TSCA  :Yes
  • HazardClass  :6.1
  • PackingGroup  :III
  • HS Code  :29093090
  • Hazardous Substances Data :91-23-6(Hazardous Substances Data)
  • NFPA 704:
    1
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H350
  • Precautionary statements P201-P301+P312+P330-P308+P313
2-Nitroanisole Price More Price(7)
  • Brand: Sigma-Aldrich(India)
  • Product number: 236284
  • Product name : 2-Nitroanisole
  • Purity: ≥99%
  • Packaging: 100G
  • Price: ₹9017.23
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: N0125
  • Product name : 2-Nitroanisole
  • Purity: min. 98.0 %
  • Packaging: 25G
  • Price: ₹1500
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: N0125
  • Product name : 2-Nitroanisole
  • Purity: min. 98.0 %
  • Packaging: 500G
  • Price: ₹4200
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-A19518-36
  • Product name : 2-Nitroanisole, 99%
  • Purity: 
  • Packaging: 500g
  • Price: ₹6763
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-A19518-0E
  • Product name : 2-Nitroanisole, 99%
  • Purity: 
  • Packaging: 2500g
  • Price: ₹43915
  • Updated: 2022/05/26
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2-Nitroanisole Chemical Properties,Usage,Production

  • Chemical Properties yellow to amber liquid
  • Chemical Properties 2-Nitroanisole is a yellowish or light-red to amber liquid. May be transported in molten form.
  • Uses 2-Nitroanisole has been employed as solvatochromic probe to examine cybotactic region of pure and mixed supercritical fluid solvent systems.
  • Uses 2-Nitroanisole is an intermediate in the synthesis of various potential therapeutic compounds.
  • Production Methods Methanolic sodium hydroxide is added slowly to a solution of 2- chloronitrobenzene in methanol at 70 ℃; the mixture is then heated gradually to 95 ℃ under pressure to complete the reaction. After dilution with water the product 2-Nitroanisole is separated as an oil, in 90 % yield, and methanol is recovered from the aqueous layer.
  • Definition ChEBI: A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group.
  • Synthesis Reference(s) Tetrahedron Letters, 29, p. 4501, 1988 DOI: 10.1016/S0040-4039(00)80531-6
  • General Description 2-Nitroanisole (2-methoxynitrobenzene is an industrial and environmental pollutant causing tumors of the urinary bladder in rats and mice. Tumorigenic potential of 2-nitroanisole has been evaluated by host-mediated in vitro and in vivo assay.
  • Hazard Questionable carcinogen.
  • Safety Profile Confirmed carcinogen. Moderately toxic by ingestion. Mutation data reported. Explosive reaction with sodium hydroxide + zinc. Vigorous reaction with hydrogen + catalyst (at 250°C/34bar). When heated to decomposition it emits toxic fumes of NOx. See also p- NITROANISOLE.
  • Potential Exposure A dye intermediate and for synthesis of other chemicals. NFPA has reported an explosion on during reduction with a nickel catalyst. Occupational exposure to 2-nitroanisole may occur through inhalation and dermal contact with this compound at workplaces where the chemical is produced or used.
  • Carcinogenicity o-Nitroanisole is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
  • Shipping UN2730 Nitroanisoles, liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3458 Nitroanisoles, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
  • Purification Methods Purify it by repeated vacuum distillation in the absence of oxygen. [Beilstein 6 IV 1249.]
  • Incompatibilities A strong oxidizer. Incompatible with strong acids; sulfur, combustibles, organics, and other easily oxidizable materials. Will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion. Explodes at temperatures ＞110℃. Combustible-liquid or fine powder may form explosive mixture with air. Nitroanisole reacts explosively with (sodium hydroxide ＋ zinc). It reacts vigorously with hydrogen1 catalyst (@ 250℃ & 25,500 mmHg).
  • Waste Disposal Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
2-Nitroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
2-Nitroanisole Suppliers
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2-Nitroanisole Spectrum
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