Hazard
Questionable carcinogen.
Potential Exposure
A dye intermediate and for synthesis
of other chemicals. NFPA has reported an explosion on
during reduction with a nickel catalyst. Occupational exposure
to 2-nitroanisole may occur through inhalation and
dermal contact with this compound at workplaces where
the chemical is produced or used.
First aid
Eyes: First check the victim for contact lenses
and remove if present. Flush victim’s eyes with water or
normal saline solution for 20 30 minutes while simultaneously
calling a hospital or poison control center. Do not
put any ointments, oils, or medication in the victim’s eyes
without specific instructions from a physician. Immediately
transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop. Skin:
immediately flood affected skin with water while removing
and isolating all contaminated clothing. Gently wash all
affected skin areas thoroughly with soap and water. If
symptoms such as redness or irritation develop, immediately
call a physician and be prepared to transport the victim
to a hospital for treatment. Inhalation: immediately
leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of
breath, or burning in the mouth, throat, or chest) develop,
call a physician and be prepared to transport the victim to a
hospital. Provide proper respiratory protection to rescuers
entering an unknown atmosphere. Whenever possible,
SCBA should be used; if not available, use a level of protection
greater than or equal to that advised under
Protective Clothing. Ingestion: do not induce vomiting. If
the victim is conscious and not convulsing, give 1 or 2
glasses of water to dilute the chemical and immediately call
a hospital or poison control center. Be prepared to transport
the victim to a hospital if advised by a physician. If the victim
is convulsing or unconscious, do not give anything by
mouth, ensure that the victim’s airway is open and lay the
victim on his/her side with the head lower than the body.
Do not induce vomiting. Immediately transport the victim
to a hospital.
Shipping
UN2730 Nitroanisoles, liquid, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials. UN3458 Nitroanisoles,
solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Incompatibilities
A strong oxidizer. Incompatible with
strong acids; sulfur, combustibles, organics, and other
easily oxidizable materials. Will accelerate the burning
of combustible materials. If large quantities are involved
in a fire or the combustible material is finely divided, an
explosion may result. Prolonged exposure to fire or heat
may result in an explosion. Explodes at temperatures
＞110℃. Combustible-liquid or fine powder may form
explosive mixture with air. Nitroanisole reacts explosively
with (sodium hydroxide ＋ zinc). It reacts vigorously
with hydrogen1 catalyst (@ 250℃ & 25,500 mmHg).
Chemical Properties
2-Nitroanisole is a yellowish or light-red to
amber liquid. May be transported in molten form.
Chemical Properties
yellow to amber liquid
Waste Disposal
Use a licensed professional
waste disposal service to dispose of this material. Dissolve
or mix the material with a combustible solvent and burn in
a chemical incinerator equipped with an afterburner and
scrubber. All federal, state, and local environmental regulations
must be observed.
Uses
2-Nitroanisole has been employed as solvatochromic probe to examine cybotactic region of pure and mixed supercritical fluid solvent systems.
Uses
2-Nitroanisole is an intermediate in the synthesis of various potential therapeutic compounds.
Definition
ChEBI: A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group.
Production Methods
Methanolic sodium hydroxide is added slowly to a solution of 2- chloronitrobenzene in methanol at 70 ℃; the mixture is then heated gradually to 95 ℃ under pressure to complete the reaction. After dilution with water the product 2-Nitroanisole is separated as an oil, in 90 % yield, and methanol is recovered from the aqueous layer.
General Description
2-Nitroanisole (2-methoxynitrobenzene is an industrial and environmental pollutant causing tumors of the urinary bladder in rats and mice. Tumorigenic potential of 2-nitroanisole has been evaluated by host-mediated in vitro and in vivo assay.
Carcinogenicity
o-Nitroanisole is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Purification Methods
Purify it by repeated vacuum distillation in the absence of oxygen. [Beilstein 6 IV 1249.]
