Kaempferol 3-O-sophoroside (10 and 20 mg/kg, p.o., once daily for 20 days) binds to AMP-activated protein kinase (AMPK) to promote brain-derived neurotrophic factor (BDNF) production and autophagy enhancement in corticosterone (HY-B1618)-induced mouse depression model and chronic unpredictable mild stress (CUMS) model, ultimately achieving antidepressant effects[3].
Kaempferol 3-O-sophoroside (100 and 200 mg/kg, p.o., 30-minute administration duration) exhibits analgesic effects in the acetic acid-induced writhing mice model[4].
| Animal Model: | Acetic acid-induced writhing mice model[4] |
| Dosage: | 50, 100, 200 mg/kg |
| Administration: | Oral gavage (p.o.), administration duration of 30 minutes |
| Result: | Caused dose-dependent inhibition of the writhing response induced by acetic acid. |
| Animal Model: | Corticosterone (HY-B1618)-induced mouse depression model; Chronic unpredictable mild stress (CUMS) model[3] |
| Dosage: | 10 and 20 mg/kg |
| Administration: | Oral gavage (p.o.), once per day for 20 consecutive days |
| Result: | Ameliorated weight loss, dyskinesia, and hippocampal volume reduction induced by Corticosterone and CUMS. |
