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Kaempferol

Pharmacological effects Mechanism of action Bioactivity

Kaempferol

CAS No.520-18-3
Chemical Name:Kaempferol
CBNumber:CB5223176
Molecular Formula:C15H10O6
Formula Weight:286.24
MOL File:520-18-3.mol

Kaempferol Property

Melting point 276°C
Boiling point 348.61°C (rough estimate)
Density 1.2981 (rough estimate)
refractive index 1.4413 (estimate)
storage temp. 2-8°C
solubility ethanol: 20 mg/mL
pka 6.34±0.40(Predicted)
form powder
Colour Index 75640
color yellow
biological source synthetic
Merck 14,5274
BRN 304401
Stability Unstable in Solution
InChIKey IYRMWMYZSQPJKC-UHFFFAOYSA-N
LogP 2.685 (est)
CAS DataBase Reference 520-18-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 731P2LE49E
IARC 3 (Vol. 31, Sup 7) 1987
UNSPSC Code 85151701
NACRES NA.77

Safety

Hazard Codes :Xi,T
Risk Statements :36/37/38-68-25
Safety Statements :26-36-45-36/37-36/37/38-22
RIDADR :2811
WGK Germany :-
RTECS :LK9275200
F :8-10-23
HS Code :29329990
Hazardous Substances Data :520-18-3(Hazardous Substances Data)

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P264-P270-P301+P312-P501

Kaempferol Price More Price(14)

Brand: Sigma-Aldrich(India)
Product number: K0133
Product name : Kaempferol
Purity: ≥90% (HPLC), powder
Packaging: 10MG
Price: ₹6743.98
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: K0133
Product name : Kaempferol
Purity: ≥90% (HPLC), powder
Packaging: 50MG
Price: ₹22364.45
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: K0133
Product name : Kaempferol
Purity: ≥90% (HPLC), powder
Packaging: 100MG
Price: ₹28329.03
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: PHR2705
Product name : Kaempferol
Purity: Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 30?mg
Packaging: 30MG
Price: ₹34066.28
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: K0133
Product name : Kaempferol
Purity: ≥90% (HPLC), powder
Packaging: 500MG
Price: ₹83255.08
Updated: 2022/06/14
Buy: Buy

Kaempferol Chemical Properties,Usage,Production

Pharmacological effects
Kaempferol (3,5,7‐trihydroxy‐2‐[4‐hydroxyphenyl]‐4H‐1‐benzopyran‐4‐one) is a yellow bioactive flavonoid, which is present inmany edible plants such as tea, cabbage, broccoli, endive, kale, beans, tomato, strawberries, leek, and grapes. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Its efficacy, a broad range of activity, and low toxicity compared with other examined compounds, make it an attractive chemical in the fight against diseases (including cancer).
Mechanism of action
Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3‐kinase (PI3K)/AKT (protein kinase B) and human T‐cell leukemia/lymphoma virus‐I (HTLV-I) signaling pathways, suppresses protein expression of epithelial‐mesenchymal transition (EMT)‐related markers including N‐cadherin, E‐cadherin, Slug, and Snail, and metastasis‐related markers such as matrix metallopeptidase 2 (MMP-2).
Bioactivity
As an anti‐oxidant, kaempferol counteracts production of superoxide ions and lowers the formation of reactive oxygen and nitrogen species. It also scavenges Fenton‐generated hydroxyl radical, peroxynitrite, and hydroxyl radicals. Furthermore, kaempferol suppresses the activity of xanthine oxidase and enhances the activities of catalase, heme oxygenase‐1, and superoxide dismutase.
Chemical Properties Yellow Solid
Uses Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.
Uses antidepressant, inhibits fatty acid amide hydrolase
Uses Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.
Definition ChEBI: Kaempferol is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment. It has a role as an antibacterial agent, a plant metabolite, a human xenobiotic metabolite, a human urinary metabolite, a human blood serum metabolite and a geroprotector. It is a member of flavonols, a 7-hydroxyflavonol and a tetrahydroxyflavone. It is a conjugate acid of a kaempferol oxoanion.
General Description Kaempferol is a polyphenolic antioxidant abundantly present in vegetables and fruits. It has a diphenylpropane structure. In many plants, it is present as a glycosidic form namely, kaempferol-3-O-glucoside.
Biological Activity Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca 2+ uniporter (EC 50 = 7 μ M). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro .
Biochem/physiol Actions Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.
Anticancer Research Kaempferol is one of the secondary metabolites found in some plants, plant-derivedfoods, and traditional medicines. It is a flavonoid compound obtained from someedible plants including grapes, tea, strawberries, broccoli, tomato, cabbage, leek,kale, endive, and beans. It inhibits growth and migration of pancreatic cancer cellsby acting on proto-oncogene tyrosine kinase (Src), ERK1/2, and AKT pathways(Singh et al. 2016a). It is being investigated in pancreatic and lung cancers toevaluate its antiangiogenic, anticancer, and radical scavenging activities. It showsmoderate cytostatic activity in PC3, HeLa, and K562 human cancer cells. It isidentified as aryl hydrocarbon receptor antagonist and acts against ABCG2 (ATP-bindingcassette subfamily G member 2)-mediated multidrug resistance bypreventing the ABCG2 upregulation in esophageal carcinoma. It induces theapoptosis of ovarian cancer cell by activating p53 in intrinsic pathway mechanism.It is an inhibitor of breast cancer resistance protein (BCRP), quinine reductase-2,and a substrate of BCRP (Calderon-Montano et al. 2011; Wang et al. 2012).
storage Store at +4°C