ChemicalBook CAS DataBase List 19895-95-5

19895-95-5

Name	kaempferol 3-O-sophoroside
CAS	19895-95-5
Molecular Formula	C27H30O16
MDL Number	MFCD01662713
Molecular Weight	610.52
MOL File	19895-95-5.mol

Synonyms

-Sophoroside Sophoraflavanoloside Sophoraflavonoloside Kaempferol 3-sophoroside Kaempferol 3-β-sophoroside kaempferol 3-O-sophoroside KaeMpferol-3-O- sophroside Kaempferol-3-O-β-D-sophoroside Kaempferol 3-O-beta-sophoroside Kaempferol 3-O-beta-D-sophoroside Phillyrin/KaeMpferol-3-O-sophoroside kaempferol3-O-β-D-glucosyl-(1→2)-β-D-glucoside kaempferol 3-O-β-D-glucosyl-(1→2)-β-D-glucoside kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 3-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyloxy)-4',5,7-trihydroxyflavone 3-[(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-4',5,7-trihydroxyflavone 3-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]-4',5,7-trihydroxyflavone 4H-1-Benzopyran-4-one, 3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)- 3-[(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Chemical Properties

Melting point	194-198℃
Boiling point	995.0±65.0 °C(Predicted)
density	1.82
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	6.20±0.40(Predicted)
color	Light Yellow
InChIKey	LKZDFKLGDGSGEO-CCMCOHMBNA-N

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Toxicity	LD50 intraperitoneal in mouse: > 1gm/kg less more

Hazard Information

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from mulberry leaves, Hedyotis diffusa, and roses.

Uses

Kaempferol 3-β-Sophoroside is a derivative of Kaempferol (K100000), a plant flavonoid which play a beneficial role in human health promotion.

Definition

ChEBI: A kaempferol O-glucoside that is kaempferol attached to a beta-D-sophorosyl residue at position 3 via a glycosidic linkage.

in vivo

Kaempferol 3-O-sophoroside (10 and 20 mg/kg, p.o., once daily for 20 days) binds to AMP-activated protein kinase (AMPK) to promote brain-derived neurotrophic factor (BDNF) production and autophagy enhancement in corticosterone (HY-B1618)-induced mouse depression model and chronic unpredictable mild stress (CUMS) model, ultimately achieving antidepressant effects^[3]. Kaempferol 3-O-sophoroside (100 and 200 mg/kg, p.o., 30-minute administration duration) exhibits analgesic effects in the acetic acid-induced writhing mice model^[4].

Animal Model:	Acetic acid-induced writhing mice model^[4]
Dosage:	50, 100, 200 mg/kg
Administration:	Oral gavage (p.o.), administration duration of 30 minutes
Result:	Caused dose-dependent inhibition of the writhing response induced by acetic acid.

Animal Model:	Corticosterone (HY-B1618)-induced mouse depression model; Chronic unpredictable mild stress (CUMS) model^[3]
Dosage:	10 and 20 mg/kg
Administration:	Oral gavage (p.o.), once per day for 20 consecutive days
Result:	Ameliorated weight loss, dyskinesia, and hippocampal volume reduction induced by Corticosterone and CUMS.

IC 50

TLR2; TLR4

Spectrum Detail

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