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Herbacetin

Herbacetin Structure
Herbacetin
  • CAS No.527-95-7
  • Chemical Name:Herbacetin
  • CBNumber:CB21074417
  • Molecular Formula:C15H10O7
  • Formula Weight:302.24
  • MOL File:527-95-7.mol
Herbacetin Property
  • Melting point 284℃
  • Boiling point 618.7±55.0 °C(Predicted)
  • Density 1.799
  • storage temp. -20°C
  • solubility DMF:30.0(Max Conc. mg/mL);99.26(Max Conc. mM)
    DMSO:30.0(Max Conc. mg/mL);99.26(Max Conc. mM)
    DMSO:PBS(pH 7.2) (1:4):1.0(Max Conc. mg/mL);3.31(Max Conc. mM)
    Ethanol:2.0(Max Conc. mg/mL);6.62(Max Conc. mM)
  • form A crystalline solid
  • pka 6.49±0.40(Predicted)
  • color Light yellow to yellow
  • LogP 1.140 (est)
  • FDA UNII 736854V2KE
  • UNSPSC Code 41116107
  • NACRES NA.25
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301
  • Precautionary statements P301+P310

Herbacetin Chemical Properties,Usage,Production

  • Chemical Properties Soluble in methanol, ethanol, DMSO and other organic solvents, derived from the aerial part of Equisetum, Rhodiola rosea.
  • Uses Herbacetin is a flavonol compound, and a natural inhibitor of E.coli β-glucuronidase. Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells. Molecular docking study of flavonoid compounds as an inhibitor of β-ketoacyl acyl carrier proteinsynthase II of Pseudomonas aeruginosa.
  • Definition ChEBI: Herbacetin is a pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities. It has a role as an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, a plant metabolite, an antilipemic drug, an anti-inflammatory agent and an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor. It is a pentahydroxyflavone and a 7-hydroxyflavonol. It is functionally related to a kaempferol.
  • Biological Activity Herbacetin is a natural flavonoid in flaxseed with a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Gluprotamine is an allosteric inhibitor of Ornithine decarboxylase (ODC), which directly binds to Asp44, Asp243 and Glu384 on ODC.
  • in vivo

    Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO) .Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; BW) decreases the number and size of polyps in APCM in+ mice with no overt toxicity.

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Herbacetin Preparation Products And Raw materials
Raw materials
Preparation Products
Herbacetin Suppliers
Global(166)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
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  • ProdList：29730
  • Advantage：60
  • Supplier：
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  • Country：China
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Herbacetin Spectrum
527-95-7, HerbacetinRelated Search:
  • Penta-substituted Flavones
  • standardized herbal extract
  • reference standards from Chinese medicinal herbs (TCM).
  • phytochemical
  • pharmaceutical intermediate
  • chemical reagent
  • 黄酮类
  • 抑制剂
  • 天然产物
  • 试剂
  • 标准品-对照品
  • 标准品，对照品
  • 标准品 -中药标准品
  • 标准品-中药标准品
  • 分析试剂标准品
  • 植物提取物
  • 标准品
  • 植提标准品
  • 中药对照品
  • 对照品
  • 草质素,10 MM DMSO 溶液
  • 3,5,7,8-四羟基-2-(4-羟基苯基)-4H-苯并吡喃-4-酮
  • 3,4',5,7,8-五羟基黄酮
  • 草质素(对照品)
  • 蜀葵苷元、蜀葵苷元
  • 草质素(蜀葵苷元,蜀葵甙元
  • 蜀葵苷元对照品,
  • 草棉黄素
  • 草质素( 蜀葵苷元
  • 草质素, 来源于红景天
  • 8-五羟基黄酮)
  • 草质素(蜀葵苷元,蜀葵甙元,3,4′,5,7,8-五羟基黄酮)
  • 蜀葵苷元
  • 蜀葵甙元
  • 3,4′,5,7,8-五羟基黄酮
  • 草质素
  • 草质素(标准品)
  • 527-95-7
  • Herbacetin, 10 mM in DMSO
  • Herbacetin-RM
  • 3,4',5,7,8-pentahydroxyflavone
  • Herbacetin,inhibit,Inhibitor
  • 3,5,7,8,4'-Pentahydroxyflavone/3,5,7,3',4',8-Hexahydroxyflavone - Herbacetin/Gossypetin mixture
  • Herbacetin, 98%, from Rhodiola rosea L.
  • 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one
  • 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one
  • Herbacetin 8-Hydroxykaempferol
  • 4H-1-Benzopyran-4-one,3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-
  • 4',5,7,8-Tetrahydroxyflavonol
  • Isoarticulatidin
  • 3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • HERBACETIN(P)(PLEASE CALL)
  • 3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

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