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7,8-Dihydroxycoumarin

CAS No.486-35-1
Chemical Name:7,8-Dihydroxycoumarin
CBNumber:CB0410069
Molecular Formula:C9H6O4
Formula Weight:178.14
MOL File:486-35-1.mol

7,8-Dihydroxycoumarin Property

Melting point 265-268°C (dec.)
Boiling point 270.35°C (rough estimate)
Density 1.3431 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. room temp
solubility soluble in Methanol
form solid
pka 7.61±0.20(Predicted)
color White to Light yellow to Light red
biological source synthetic (organic)
Merck 14,2817
InChI InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
InChIKey ATEFPOUAMCWAQS-UHFFFAOYSA-N
SMILES C1(=O)OC2=C(O)C(O)=CC=C2C=C1
LogP 0.884 (est)
CAS DataBase Reference 486-35-1(CAS DataBase Reference)
FDA UNII XC84571RD2
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :Xi
Risk Statements :25-36/37/38-20/21
Safety Statements :22-24/25-36-26-36/37/39
WGK Germany :2
RTECS :GN6382600
HS Code :29322090

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319
Precautionary statements P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

7,8-Dihydroxycoumarin Price More Price(6)

Brand: Sigma-Aldrich(India)
Product number: D5564
Product name : 7,8-Dihydroxycoumarin
Purity: ≥97%, powder
Packaging: 5MG
Price: ₹8714.13
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: D5564
Product name : 7,8-Dihydroxycoumarin
Purity: ≥97%, powder
Packaging: 25MG
Price: ₹36783.35
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: D4001
Product name : Daphnetin
Purity:
Packaging: 1G
Price: ₹15000
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: D4001
Product name : Daphnetin
Purity:
Packaging: 5G
Price: ₹34800
Updated: 2022/05/26
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Brand: ottokemi
Product number: D 0355
Product name : Daphnetin+
Purity: 97%
Packaging: 5mg
Price: ₹7902
Updated: 2022/05/26
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7,8-Dihydroxycoumarin Chemical Properties,Usage,Production

Description Daphnetin, mainly extracted from Yu Ruixiang Changbai Daphne (Daphne Korean Nakai), Daphne giraldii Nitsche bark, and root bark, is the main efficacy component of the plants D.tangutica Maxim and D.retttsa Hemsl. Changbai daphnes has the pharmacological effects of warming the spleen and stomach, relaxing the muscles and joints, and promoting circulation. In TCM, it’s commonly used as medicines for treatment of injuries. Because Changbai daphne is a pungent and warm natured herbal medicine, it was used to warm the spleen and stomach by dispelling cold.
Physical properties Appearance: white or off-white powder, odorless, and tasteless; Solubility: slightly soluble in methanol (equilibrium solubility of 485.4? μg/mL), slightly soluble in ethanol (equilibrium solubility of 230.06?μg/mL), and insoluble in water (equilibrium solubility of 176.7?μg/mL) ; Melting point: 262–264?°C.
History Changbai daphne, a Chinese traditional medicine in clinic, is mainly used for treatment of coronary heart disease, rheumatoid arthritis, thromboangiitis obliterans, etc. Changbai daphne belongs to the first-class protective plants in Jilin province in China, and the rarity restricted the drug development. Scientists tried to find the effective components of Changbai daphne. In 1977, scientists of phytochemistry research group in the Traditional Chinese Medicine research laboratory from Jilin institute of Chinese medicine first successfully isolated the crystalline monomer?– daphnetin?– from the plant. Pharmacological results show that the pharmacological activities of this crystal are equal to Changbai daphne, which suggested the crystal is the main active ingredient . Through the condensation reaction experiment using equimolecular pyrogallic acid, malic acid, and twice the amount of sulfuric acid, under heating reaction, scientists successfully got pale yellow needle daphnetin crystals. From then on artificially synthesized daphnetin has been successfully implemented . A large-scale industrial production can be acquired. The followup researches on the metabolism and pharmacological activity of daphnetin were carried out. In 2009, the State Food and Drug Administration of China approved daphnetin capsule to be used in the clinical.
Uses Daphnetin is a natural coumarin derivative providing anti-inflammatory and protective properties to those suffering from lung injury.
Indications This product is contained in national standards for chemical drugs, mainly used in Buerger’s disease, occlusive vascular disease, and coronary heart disease.
Definition ChEBI: 7,8-dihydroxycoumarin is a hydroxycoumarin.
General Description This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions 7,8-Dihydroxycoumarinan is an inhibitor of protein kinases. It is an active lactone present in plants such as Daphne Korean Nakai, and Thymelaeaceae Daphne. It serves as as analgesic, antiviral and antibacterial agent. 7,8-Dihydroxycoumarinan is found to induce tumor apoptosis via a number of signalling pathways. Thus, it is believed to exhibit antitumor effects. 7,8-Dihydroxycoumarinan might also be useful in treating lung carcinoma. It is also known to be used in treating coagulation disorders and rheumatoid arthritis. 7,8-Dihydroxycoumarinan is known to induce neurite growth and lengthen neuronal survival. It helps in clearing substances inducing necrosis, maintains water-electrolytes balance and energy metabolism. 7,8-Dihydroxycoumarinan is involved in the generation of neurotrophic factor and helps in restoring neuron function.
Pharmacology Daphnetin pharmacological effect mainly includes: 1. Improvement of the cardiovascular system function； 2. Effects on the central nervous system. Daphnetin also acts on the NF-k B and NFAT signal pathway and results in immune inhibition; it is also used for the treatment of malaria parasite and Pneumocystis carinii infection by chelating to Fe2 + or by acting on ribonucleotide reductase; daphnetin shows bacteriostatic effects on gold grapes, Escherichia coli, Shigella’s blessing, and Pseudomonas aeruginosa by inhibiting succinic acid oxidase in mitochondria in bacteria; daphnetin reduces the incidences of diarrhea in model mice by inhibiting mice gastrointestinal propulsive movement and has a stronger toxic effect on several important aphids .
Plasma protein binding of Daphetin is low. The urinary excretion is higher. The distribution volume is relatively larger. Both of metabolism and excretion are rapid. Drug elimination is mainly through the kidney with a half-life of only 15 min. The tissue distributions after intravenous injection and oral administration are equal. Daphnetin may distribute in the brain through the blood-brain barrier. The metabolites have poor stability and low oral bioavailability. People have studied the metabolic pathways and metabolic product. Daphnetin may be the substrates of MRP2 and BCRP transporters, and thus intestinal absorption is affected; in the plasma of rats, the main metabolite are 7-O and 8-O glucoside substitution products which are mediated by UT1A6 and UT1A9. The anti-inflammatory activity of the metabolites is dependent on daphnetin-7-methyl ether.
Clinical Use It has been verified by a large number of clinical cases that oral daphnetin capsule can significantly improve thromboangiitis obliterans; oral daphnetin has a better curative effect than intramuscular injection of Changbai daphne in patients with angina pectoris due to coronary heart disease. Daphnetin shows an obvious analgesic sedative effect on surgical and nonsurgical pain-relieved patients after intravenous drip or injection of daphnetin; oral daphnetin capsule shows significant therapeutic effects on rheumatoid arthritis.
There are no reports about serious adverse reactions. Two cases of whole-body red itch were reported. It sometimes has mild gastrointestinal reaction when continuously used.
storage Room temperature
Purification Methods Crystallise it from aqueous EtOH. It can be sublimed. [Beilstein 18/3 V 202.].