ChemicalBook > CAS DataBase List > (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL

(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL

(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL Structure
(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
  • CAS No.3947-65-7
  • Chemical Name:(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
  • CBNumber:CB1262623
  • Molecular Formula:C12H26N4O6
  • Formula Weight:322.36
  • MOL File:3947-65-7.mol
(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL Property
  • Melting point 225.5°C (rough estimate)
  • Boiling point 460.98°C (rough estimate)
  • alpha D25+112.8° (c = 1)
  • Density 1.1885 (rough estimate)
  • refractive index 1.6120 (estimate)
  • storage temp. Hygroscopic, Refrigerator, Under inert atmosphere
  • solubility Aqueous Acid (Slightly), Methanol (Slightly, Heated), Water (Slightly)
  • pka 13.24±0.70(Predicted)
  • form Solid
  • color White to Pale Yellow
  • Stability Hygroscopic
  • FDA UNII 5981U00LY0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313

(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL Chemical Properties,Usage,Production

  • Uses Neamine is normally found as a core structure of aminoglycoside antibiotics. It is used in the synthesis of disaccharide neamine derivatives as antibacterial agents.
  • Definition ChEBI: 2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group.
  • in vivo

    Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts[1].

    Animal Model:Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells[1]
    Dosage:30 mg/kg, 60 mg/kg
    Administration:Subcutaneous injection; daily; for 14 days
    Result:Had anti-tumor effects on AsPC-1 xenograft models.
  • IC 50 Aminoglycoside
(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL Preparation Products And Raw materials
Raw materials
Preparation Products
(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL Suppliers
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(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL Spectrum
3947-65-7, (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOLRelated Search:
  • Intermediates
  • 化学试剂
  • 杂质对照品
  • 对照品-杂质对照品
  • C12H26N4O6
  • (2R,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-(((1 R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHE XYL)
  • (3S,5R,6R)-5-氨基-2-(氨基甲基)-6-(((1R,3S)-4,6-二氨基-2,3-二羟基环己基)氧基)四氢-2H-吡喃-3,4-二醇
  • 妥布霉素杂质3
  • 妥布霉素杂质3 (妥布霉素杂质 C )(新霉胺)
  • 硫酸新霉素杂质1(硫酸新霉素EP杂质A)
  • 硫酸新霉素EP杂质A(妥布霉素EP杂质C)(新霉胺对照品)
  • 硫酸新霉素杂质 A
  • 硫酸新霉素EP杂质A(NEAMINE)
  • 硫酸弗雷米锡EP杂质A
  • 新霉素 EP标准品
  • 新霉素杂质A
  • 新霉素杂质A(EP)
  • 硫酸新霉素EP杂质A
  • 工厂已不再生产
  • 新黴素A
  • 新霉胺
  • 3947-65-7
  • Neomycin A Sulfate (Neamine), EvoPure
  • Neomycin Sulfate EP Impurity A（Tobramycin EP Impurity C）
  • 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine (neamine)
  • Neamine (synonym: Neomycin Sulfate EP Impurity A)
  • Neamine CRS
  • NEAMINE
  • Neomycin Sulfate EP Impurity A (Neamine)Q: What is Neomycin Sulfate EP Impurity A (Neamine) Q: What is the CAS Number of Neomycin Sulfate EP Impurity A (Neamine) Q: What is the storage condition of Neomycin Sulfate EP Impurity A (Neamine) Q: What are the applications of Neomycin Sulfate EP Impurity A (Neamine)
  • Neamine (N0300000)Q: What is Neamine (N0300000) Q: What is the CAS Number of Neamine (N0300000) Q: What are the applications of Neamine (N0300000)
  • Framycetin sulfate EP Impurity A
  • Framycetin Impurity 1 (Framycetin EP Impurity A)
  • (1R,3S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
  • (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4-diol
  • Tobramycin Impurity 3 (Tobramycin EP Impurity C) (Neamine)
  • Framycetin EP Impurity A
  • D-Streptamine, 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-
  • Neomycin Sulfate EP Impurity A
  • Neomycin Sulfate EP Impurity A (Neamine)
  • Neomycin Sulfate Impurity 1（Neomycin Sulfate EP Impurity A）
  • Neomycin sulfate impurity A
  • 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine (neamine or neomycin A-LP)
  • 5-amino-2-(aminomethyl)-6-(4,6-diamino-2,3-dihydroxycyclohexyl)oxyoxane-3,4-diol
  • Neomycin A sulfate (Neamine)
  • C01441
  • Negamicin
  • 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine
  • neomycina
  • nebramycinx
  • neamin
  • dekamycinv
  • (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
  • 2-deoxy-4-o-(2,6-diamino-2,6-dideoxy-alpha-d-glucopyranosyl)-d-streptamin
  • U-5214
  • 5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL

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