ChemicalBook > CAS DataBase List > N3-PEG3-tBu
N3-PEG3-tBu
N3-PEG3-tBu
- CAS No.252881-73-5
- Chemical Name:N3-PEG3-tBu
- CBNumber:CB12546985
- Molecular Formula:C13H25N3O5
- Formula Weight:303.3547
- MOL File:252881-73-5.mol
N3-PEG3-tBu Property
- form Liquid
- color Colorless to light yellow
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
N3-PEG3-tBu Chemical Properties,Usage,Production
- Description Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
- Uses Azido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides.
- Biological Activity N3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules.
-
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. -
target
PEGs
Alkyl/ether
Cleavable
N3-PEG3-tBu Preparation Products And Raw materials
Raw materials
Preparation Products
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252881-73-5, N3-PEG3-tBuRelated Search:
- Azido-dPEG4-acid alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) Amino-PEG4-acid O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL PEG-Azide, O-(2-Azidoethyl)-Oμ-methylpolyethylene glycol Z-9-aMino-4,7-dioxanonanoic acid 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-amine Amino-PEG6-alcohol O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL) N3-PEG4-tBu H2N-PEG8-tBu 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AZIDE Amino-PEG8-azide AMINO-PEG12-T-BUTYL ESTER H2N-PEG6-tBu 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amine Azido-PEG11-azide
- peg
- SiChem
- 抑制剂
- PEG系列产品-N3-PEG系列
- 药靶配体
- 聚乙二醇修饰剂
- 叠氮-PEG3-TBU酯
- 化合物 N3-PEG3-CH2CH2-BOC
- 3-(2-(2-(2-叠氮乙氧基)乙氧基)乙氧基)丙酸叔丁酯
- 叠氮三聚乙二醇缬氨酸叔丁酯
- 叠氮-三聚乙二醇-叔丁酯
- 3-[2-[2-(2-叠氮基乙氧基)乙氧基]乙氧基]丙酸叔丁酯
- 叠氮-三乙二醇-丙酸叔丁酯
- 3-[2-[2-(2-叠氮基乙氧基)乙氧基]乙氧基]丙酸叔丁酯
- 3-[2-[2-(2-叠氮基乙氧基)乙氧基]乙氧基]丙酸叔丁酯 1G
- 252881-73-5
- N3-PEG3-CH2CH2COO<SUP>t<
- Azido-PEG3-CH2CH2COOtBu
- N3-PEG3-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
- Azido-PEG3-tBu Ester
- N3-(CH2CH2O)3-CH2CH2COOt-Bu
- N?-PEG?-CH?CH?COOtBu
- N3-PEG3-CH2CH2-Boc
- N3-?PEG3-?t-?butyl ester
- tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate
- Azido-PEG3-COOtBu
- tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate
- 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester
- N3-PEG3-CH2CH2COOtBu
- N3-PEG3-tBu
- N<SUB>3</SUB>-PEG<SUB>3</SUB>-CH<SUB>2</SUB>CH<SUB>2</SUB>COO<SUP>t</SUP>Bu