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N3-PEG4-tBu

N3-PEG4-tBu Structure
N3-PEG4-tBu
  • CAS No.581066-04-8
  • Chemical Name:N3-PEG4-tBu
  • CBNumber:CB72546987
  • Molecular Formula:C15H29N3O6
  • Formula Weight:347.40726
  • MOL File:581066-04-8.mol
N3-PEG4-tBu Property
  • refractive index 1.449 (589.3 nm 23℃)
  • form Liquid
  • color Colorless to light yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

N3-PEG4-tBu Chemical Properties,Usage,Production

  • Description Azido-PEG4-t-butyl ester is a click chemistry linker containing an azide (N3) and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group is reactive toward alkyne, BCN, DBCO via Click Chemistry . The t-butyl protected carboxyl group can be deprotected under acidic conditions.
  • Uses Azido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • IC 50 PEGs; Alkyl/ether
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N3-PEG4-tBu Preparation Products And Raw materials
Raw materials
Preparation Products
N3-PEG4-tBu Suppliers
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N3-PEG4-tBu Spectrum
581066-04-8, N3-PEG4-tBuRelated Search:
  • peg
  • SiChem
  • PEG系列产品-N3-PEG系列
  • 配体家族
  • 基准试剂
  • 聚乙二醇修饰剂
  • C15H29N3O6
  • 1-叠氮-3,6,9,12-四氧杂十五烷-15-酸叔丁酯
  • 1,1-二甲基乙基15-氮杂-4,7,10,13-四氧基己酸酯
  • 叠氮四聚乙二醇缬氨酸叔丁酯
  • 叠氮-四聚乙二醇-叔丁酯
  • 叠氮-四乙二醇-丙酸叔丁酯
  • 叠氮-四聚乙二醇-丙酸叔丁酯
  • 15-叠氮基-4,7,10,13-四氧杂十五烷酸叔丁酯
  • 581066-04-8
  • N3-PEG4-CH2CH2COO<SUP>t<
  • Azido-PEG4-CH2CH2COOtBu
  • N3-PEG4-tBul
  • N3-PEG4-CH2CH2COOtBu/4,7,10,13-Tetraoxapentadecanoic acid, 15-azido-, 1,1-dimethylethyl ester
  • Azido-PEG4-tBu Ester
  • Azido-PEG4-tButly ester
  • Azido-PEG4-Boc
  • N3-?PEG4-?t-?butyl ester
  • Azido-PEG4-COOtBu
  • Azido-PEG5-t-butyl ester
  • N<SUB>3</SUB>-PEG<SUB>4</SUB>-CH<SUB>2</SUB>CH<SUB>2</SUB>COO<SUP>t</SUP>Bu
  • 15-Azido-4,7,10,13-tetraoxapentadecanoic acid 1,1-dimethylethyl ester
  • N3-PEG4-CH2CH2COOtBu
  • N3-PEG4-tBu

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