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Fluorescein Sodium

CAS No.518-47-8
Chemical Name:Fluorescein Sodium
CBNumber:CB0753559
Molecular Formula:C20H13NaO5
Formula Weight:356.31
MOL File:518-47-8.mol

Fluorescein Sodium Property

Melting point 320 °C
Density 0.579[at 20℃]
bulk density 600kg/m3
vapor pressure 2.133hPa
storage temp. Store at +5°C to +30°C.
solubility H2O: soluble1mg/mL
Colour Index 45350
form Powder
pka 2.2, 4.4, 6.7(at 25℃)
color Rust-orange
PH 8.3 (10g/l, H2O, 20℃)
PH Range Pink uorescence (4.0) to green uorescence (6.0)
Odor Odorless
Water Solubility 500 g/L (20 ºC)
λmax 491nm, 493.5nm, 490nm
Merck 14,4159
BRN 3833041
Stability Stable.
Major Application Nanolithography, nanoparticles, thin films, fuel cells, inks, laser, colored bubbles, cleansing products, identifying leaks in coolant, suntanning agent, hair dyes, cosmetics, dermatology, dental material, diagnosis of diabetic retinopathy, antitumor agent
InChIKey NJDNXYGOVLYJHP-UHFFFAOYSA-L
LogP 0.34
FDA 21 CFR 74.1708; 74.2708; 74.3708; 82.1708
CAS DataBase Reference 518-47-8(CAS DataBase Reference)
EWG's Food Scores 1-3
FDA UNII 93X55PE38X
NCI Drug Dictionary Fluorescite
EPA Substance Registry System Fluorescein, disodium salt (518-47-8)
UNSPSC Code 85151701
NACRES NB.21

Safety

Hazard Codes :Xi
Risk Statements :36-36/37/38
Safety Statements :22-24/25-37/39-26-36/37/39-27
WGK Germany :1
RTECS :LM5425000
F :3
TSCA :Yes
HS Code :32041200
Hazardous Substances Data :518-47-8(Hazardous Substances Data)
Toxicity :LD50 in mice, rats (mg/kg): 4738, 6721 orally (Yankel, Loux)

NFPA 704:

	1
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319
Precautionary statements P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Fluorescein Sodium Price More Price(21)

Brand: Sigma-Aldrich(India)
Product number: F6377
Product name : Fluorescein sodium salt
Purity: used as fluorescent tracer
Packaging: 100G
Price: ₹3410
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: F6377
Product name : Fluorescein sodium salt
Purity: used as fluorescent tracer
Packaging: 500G
Price: ₹7592.4
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 46970
Product name : Fluorescein sodium salt
Purity: p.a., for source staining
Packaging: 100G
Price: ₹4206.9
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 46960
Product name : Fluorescein sodium salt
Purity: BioReagent, suitable for fluorescence
Packaging: 25G
Price: ₹1887
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 46970
Product name : Fluorescein sodium salt
Purity: p.a., for source staining
Packaging: 500G
Price: ₹12554.1
Updated: 2022/06/14
Buy: Buy

Fluorescein Sodium Chemical Properties,Usage,Production

Chemical Properties Orange-red powder; odorless. Hygroscopic, soluble in water; sparingly soluble in alcohol.
Uses In examining subterranean waters. Serves to ascertain source of springs, connections between streams and sea, determining approx vol of water delivered by a spring, detecting source of contamination of drinking water, infiltration of soil with waste waters of factories. In externally applied drugs and cosmetics. Analytical reagent (protein label). Clinical reagent (immuno-histological stain, immuno-fluorescent label).
Uses Fluorescein sodium salt is a sodium salt of fluorescein. It can also be used in technical or engineered material use in-situ photochemical fabrication of transition metal-?promoted amorphous molybdenum sulfide catalysts for enhanced photosensitized hydrogen evolution. Dyes and metabolites, Environmental Testing
General Description Fluorescein sodium is an orange-red to dark red powder. Water-soluble form of fluorescein. Odorless and almost tasteless. pH (5% solution) 7.8. May be sensitive to prolonged exposure to light and to heat.
Air & Water Reactions Hygroscopic. Water soluble.
Reactivity Profile Fluorescein disodium salt is incompatible with strong oxidizers. Also incompatible with acids, acid salts and salts of heavy metals .
Fire Hazard Flash point data for Fluorescein disodium salt are not available; however, Fluorescein disodium salt is probably combustible.
Safety Profile Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Human systemic effects by intravenous route: arrhythmias, eye hemorrhage, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Na2O.
Veterinary Drugs and Treatments Fluorescein sodium is a yellow water-soluble dye that fluoresces under a Wood’s Lamp, but is plainly visible after binding to corneal stroma through an ophthalmic examination light source. It is used most commonly to delineate full thickness loss of corneal epithelium indicating the presence of a corneal ulceration. In this instance it will stain the corneal stroma. The epithelium is not stained because its outer lipid cell membrane repels the stain. Descemet’s membrane will not stain with fluorescein stain and this is used to indicate descemetocele formation, an ocular emergency.
Fluorescein stain is applied to the precorneal tear film in dogs and cats and the break-up of this stain with time, as observed through a slit lamp biomicroscope using a cobalt blue light source, is used to determine the tear film break-up time (normal 19 seconds), an indicator of tear film quality.
Fluorescein stain is applied to the tear film of dogs to determine patency of the nasolacrimal outflow system. The normal wait time is 2 – 5 minutes in dogs and up to 10 minutes in cats. A positive test indicates patency of the system. A negative test is not indicative of disease as the test is negative in a large percentage of normal animals. Fluorescein stain, then, can be added to irrigating solution to flush the nasolacrimal system, making detecting the irrigation solution at the nose more obvious during flushing of the system.
Properties and Applications brilliant yellow. Soluble in water and ethanol (with strong green fluorescent), water-soluble good. In strong sulfuric acid with weak for fluorescence yellow, it will be diluted with yellow precipitation. Its water solution and sodium hydroxide with dark green fluorescence for brunet solution. Mainly used for sea of target that fluorescent, facilitate aerial reconnaissance search. And can use significantly for the exploration of fluorescent groundwater. Can also be used for medicine and cosmetics shading, rarely used for silk printing and dyeing things.