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Eosin Disodium

CAS No.17372-87-1
Chemical Name:Eosin Disodium
CBNumber:CB9461211
Molecular Formula:C20H6Br4Na2O5
Formula Weight:691.85418
MOL File:17372-87-1.mol

Eosin Disodium Property

Melting point >300°C
Density 1.02 g/mL at 20 °C
bulk density 710kg/m3
vapor pressure 0Pa at 25℃
Flash point 11 °C
storage temp. Store at RT.
solubility H₂O: 0.1 g/mL, dark red
Colour Index 45380
form Solid
pka 2.9, 4.5(at 25℃)
color Reddish
PH 9.2 (10g/l, H2O, 20℃)
PH Range 0(yellow)-3(green fluoresc.)
Water Solubility freely soluble
λmax 514nm
Merck 14,3603
BRN 3586809
Stability Stable. Incompatible with strong oxidizing agents.
Biological Applications Treating age-related macular degeneration,burns,cancer,diabetes,obesity,dental bone defects,gastroesophageal reflux disease,prostate cancer,viral diseases; stents; wound-healing materials
Major Application Photovoltaic devices, color filter, nanoscale host material, detection of latent fingerprints, inks, detergents, hair dyes, cosmetics, implantable drug delivery devices, stents, diagnosis of breast lesions, labeling nucleic acids, detecting proteins, stress biomarkers, phosphoprotein, breast cancer metastases, antimicrobial agent, treatment of burns, endodontic, diabetes, obesity, cancer, radiochemotherapy, DNA sequencing, gene expression profiling, wound healing promoters
LogP -1.33
FDA 21 CFR 74.1322; 74.2322; 82.1322
CAS DataBase Reference 17372-87-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII D&C RED NO. 22 (1678RKX8RT)
ACID RED 87 (TDQ283MPCW)
ATC code D08AX02
EPA Substance Registry System Eosin Yellowish (YS) (17372-87-1)
UNSPSC Code 41116130
NACRES NA.54

Safety

Hazard Codes :F,T,Xn,Xi
Risk Statements :11-23/24/25-39/23/24/25-52/53-41-22-36-10
Safety Statements :7-16-36/37-45-24/25-61-39-26
RIDADR :UN 1230 3/PG 2
WGK Germany :1
RTECS :LM5850000
TSCA :Yes
HS Code :32041200
Toxicity :LD50 orally in Rabbit: > 2000 mg/kg

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H317-H319
Precautionary statements P261-P264-P280-P301+P312-P302+P352-P305+P351+P338

Eosin Disodium Price More Price(28)

Brand: Sigma-Aldrich(India)
Product number: E6003
Product name : Eosin Y disodium salt
Purity: Dye content ≥85?%
Packaging: 25G
Price: ₹3807.3
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: E6003
Product name : Eosin Y disodium salt
Purity: Dye content ≥85?%
Packaging: 100G
Price: ₹10900.2
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: E6003
Product name : Eosin Y disodium salt
Purity: Dye content ≥85?%
Packaging: 250G
Price: ₹26595.6
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: E4382
Product name : Eosin Y disodium salt
Purity: certified by the Biological Stain Commission
Packaging: 25G
Price: ₹7460
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: E4382
Product name : Eosin Y disodium salt
Purity: certified by the Biological Stain Commission
Packaging: 100G
Price: ₹16430
Updated: 2022/06/14
Buy: Buy

Eosin Disodium Chemical Properties,Usage,Production

Chemical Properties brownish-red powder
Uses Eosin is most often used as a counterstain to haematoxylin in H&E (haematoxylin and eosin) staining. H&E staining is one of the most commonly used techniques in histology.
Uses Anti Septic
Uses Eosin Yellowish noted to reduce the affinity of Mg2+-ATPase for ATP and increase the enzyme affinity for Mg2+ at concentrations of 10-50 ?M. At higher concentrations near 100 ?M the affinity for Mg2+-ATPase for the ion-activator has been shown to be reduced. This compound has also been reported to be a photosensitizer that works as a molecular photoelectrode via catalyzation of the visible-light-driven electron-transfer reaction. Eosin Y is also used to stain structures such as muscle, cytoplasm, and collagen. This agent also enhances fluorescent quenching abilities by forming a complex with polyvinulpyrrolidone.
Preparation countries called red. Fluorescent element (C.I. Acid Yellow 73, C.I. 45350) in water or ethanol solution bromine into four bromine derivatives, and then into sodium salt.
Definition ChEBI: An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.
Flammability and Explosibility Not classified
Biological Activity ami5/eosin y disodium salt is a non-selective protein methyltransferase inhibitor.post-translational protein methylation at lysine and arginine residues is related to the gene expression regulation. the enzymatic activities of protein methyltransferases serve to do covalent modifications in the control of gene transcription.
Safety Profile Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of Brand NazO. See also BROMIDES.
in vitro ami5/eosin y disodium salt has been identified as a competitive inhibitor of sam binding and had been shown to inhibit not only prmts but also lysine methylation by the set7 and disruptor of telomeric silencing 1-like (dot1l) mtases in vitro. both ami5/eosin y disodium salt and its analog ami-1 have been used as lead compounds for the development of novel mtase-specific inhibitors. moreover, it was found that ami5/eosin y disodium salt could inhibit set7 in vitro and decrease h3k4m1 in vascular endothelial cells. [1].
IC 50 0.78 and 1.41 μm for hmt1p and prmt1, respectively
storage +4°C
Purification Methods Dissolve it in the minimum volume of H2O (1g/mL), filter and add EtOH until separation of salt is complete. Filter the solid off, wash it with absolute EtOH, then Et2O and dry it first in air, then at 100o. It is used for staining blood cells and for estimating traces of Ag. [Selsted & Becker Anal Biochem 155 270 1986, El-Ghamry & Frei Anal Chem 40 1986 1968.] [Beilstein 19 III/IV 2917.] [See above]

Properties and Applications yellow peach. Orange powder, soluble in water and ethanol with fluorescent blue light is yellowish red solution. Meet strong sulfuric acid yellow, it will be diluted yellow light red precipitate generated. Dyeing copper ions in the blue colour and lustre; Iron ion colour and lustre in the dark blue. Discharge the gender is good. Mainly used in red ink and red pencils, only comfortable carpet dyeing. After refining can be used as medicine and cosmetics of coloring. Can also be used in leather dyeing. The aluminum salt can be used as organic pigments.

Standard	Light Fastness	Soaping		Persperation Fastness	Oxygen bleaching		Fastness to seawater
Standard	Light Fastness	Fading	Stain	Persperation Fastness	Fading	Stain	Fading	Stain
ISO	2	3	3	2	1	2	2	2
AATCC	1	2	2	3	1	1	3	3

References [1] okabe j,fernandez az,ziemann m,keating st,balcerczyk a,el-osta a. endothelial transcriptome in response to pharmacological methyltransferase inhibition. chemmedchem.2014 aug;9(8):1755-62.