Synthesis
In certain instances, when both chloro and nitro may act as a leaving group, a
surprising selectivity of one over the other is observed, for example chloro-2,5-
dinitrobenzene was converted to 4-fluoro-3-chloronitrobenzene.
Chemical Properties
white to light yellow crystal powder
Uses
2-Chloro-1-fluoro-4-nitrobenzene has been used in synthesis of:
- benzoimidolones on Ameba resin
- methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate
Uses
2-Chloro-1-fluoro-4-nitrobenzene is an intermediate used in synthesis of benzoimidolones on Ameba resin and methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate.
General Description
2-Chloro-1-fluoro-4-nitrobenzene undergoes reduction in the presence of Mo(CO)
6 and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under microwave irradiation to yield a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline.
