Chemical Properties
colourless to yellow crystals or beige powder
Uses
1,2-Dichloro-4-nitrobenzene is an intermediate in the synthesis of agrochemicals. Studies have been conducted to use 1,2-Dichloro-4-nitrobenzene as an organic intermediate for the synthetic preparation of ciprofloxacin (C482500).
Production Methods
Nitration of 1,2-dichlorobenzene with mixed acid at 35 – 60 ℃ results in a mixture of 3-nitro (10 %) and 4-nitro (90 %) isomers, which are separated by crystallization. A more expensive process (two stages from chlorobenzene) is based on chlorination of molten 4-chloronitrobenzene (90 – 100 ℃) by a process similar to that used for 3- chloronitrobenzene production. Chlorination has the advantage of giving a pure product, but it cannot be used if the isomeric 1,2-dichloro-3-nitrobenzene is also required.
Synthesis Reference(s)
The Journal of Organic Chemistry, 42, p. 3494, 1977
DOI: 10.1021/jo00442a009
General Description
Colorless crystals or light beige solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Can react vigorously with oxidizing materials.
Fire Hazard
3,4-Dichloronitrobenzene is combustible.
Flammability and Explosibility
Non flammable
Purification Methods
Crystallise it from absolute EtOH. [Beilstein 5 IV 726.]
