Chemical properties Uses Production Category Toxicity grading Acute toxicity Hazardous characteristics of the explosive Flammability hazard Storage and transportation properties Extinguishing agent
ChemicalBook > CAS DataBase List > Gamma Butyrolactone

Gamma Butyrolactone

Chemical properties Uses Production Category Toxicity grading Acute toxicity Hazardous characteristics of the explosive Flammability hazard Storage and transportation properties Extinguishing agent
Gamma Butyrolactone Structure
Gamma Butyrolactone
  • CAS No.96-48-0
  • Chemical Name:Gamma Butyrolactone
  • CBNumber:CB9719491
  • Molecular Formula:C4H6O2
  • Formula Weight:86.09
  • MOL File:96-48-0.mol
Gamma Butyrolactone Property
  • Melting point: :-45 °C (lit.)
  • Boiling point: :204-205 °C (lit.)
  • Density  :1.12 g/mL at 25 °C (lit.)
  • vapor density  :3 (vs air)
  • vapor pressure  :1.5 mm Hg ( 20 °C)
  • refractive index  :n20/D 1.436(lit.)
  • Flash point: :209 °F
  • storage temp.  :2-8°C
  • form  :neat
  • color  :Clear colorless
  • PH Range :4 at 100 g/l at 20 °C
  • explosive limit :16%
  • Water Solubility  :MISCIBLE
  • Merck  :13,1596
  • JECFA Number :219
  • BRN  :105248
  • Stability: :Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong acids, strong bases, strong reducing agents.
  • CAS DataBase Reference :96-48-0(CAS DataBase Reference)
  • Substances Added to Food (formerly EAFUS) :4-HYDROXYBUTANOIC ACID LACTONE
  • EWG's Food Scores :1
  • NIST Chemistry Reference :«gamma»-Butyrolactone(96-48-0)
  • IARC :3 (Vol. 11, Sup 7, 71) 1999
  • EPA Substance Registry System :.gamma.-Butyrolactone (96-48-0)
  • Pesticides: Freedom of Information Act (FOIA) :Butyrolactone
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H315-H302-H318-H336
  • Precautionary statements P280a-P301+P312a-P310a-P321-P501a-P261-P280-P305+P351+P338
Gamma Butyrolactone Price More Price(15)
  • Brand: Sigma-Aldrich
  • Product number: W329118
  • Product name : 4-Hydroxybutanoic acid lactone
  • Purity: ≥98%, FCC, FG
  • Packaging: 1 kg
  • Price: $70
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: B103608
  • Product name : γ-Butyrolactone
  • Purity: ≥99%
  • Packaging: 2.5kg
  • Price: $102
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: W329118
  • Product name : 4-Hydroxybutanoic acid lactone
  • Purity: ≥98%, FCC, FG
  • Packaging: 10 kg
  • Price: $270
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: W329118
  • Product name : 4-Hydroxybutanoic acid lactone
  • Purity: ≥98%, FCC, FG
  • Packaging: 25 kg
  • Price: $513
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: B103608
  • Product name : γ-Butyrolactone
  • Purity: ≥99%
  • Packaging: 20kg
  • Price: $715
  • Updated: 2021/03/22
  • Buy: Buy

Gamma Butyrolactone Chemical Properties,Usage,Production

  • Chemical properties Gamma-Butyrolactone (GBL) is a colorless oily liquid. It is miscible with water and the general organic and slightly soluble in aliphatic hydrocarbons. GBL has been characterized as having an intense bitter taste with faint to pleasant odor.
  • Uses Gamma-Butyrolactone (GBL) has widespread industrial use. It is a common solvent found in paint strippers, nail polish removers, stain removers and circuit board cleaners. It is also a common intermediate in industrial chemistry including the manufacture of pyrrolidones and in some pharmaceuticals.
    Gamma-Butyrolactone is an important organic synthesis intermediate which can be used to synthesize indole butyric acid, butyric acid, succinic acid, α-pyrrolidone, N-methylpyrrolidone, vinyl pyrrolidone, acetyl-γ-butyrolactone, cyclopropylamine, ciprofloxacin, vitamin B1, chlorophyll and so on;
    It is a non-toxic high boiling point solvent with high solubility and safe and convenient usage and management;
    It is used as an extractant for butadiene, aromatic, advanced grease petroleum processing;
    It is used as an acrylonitrile fiber spinning solvent in the chemical fiber industry.
    It is a thinner and curing agent commonly used in wool, nylon, acrylonitrile and other fiber dyeing auxiliaries and other chemical industries.
  • Production Maleic anhydride hydrogenation method is an advanced technology developed in 1970s. It can produce tetrahydrofuran and γ-butyrolactone in any proportion with a hydrogenation reaction, and the usual ratio is tetrachlorofuran: γ-butyrolactone = 3-4:1.
    There are many production enterprises, but usually in small scale. The average level is 300t/a. The production capacity account for 30% of the total domestic production capacity.  2.1, 4-butanediol dehydrogenation reactor is a tube array reactor, filled with flake copper catalyst (with zinc oxide as the carrier). The reaction temperature is controlled at 230-240 ° C. The yield of the product is obtained by reduced pressure distillation of and the yield is above 77%.
  • Category Flammable substance
  • Toxicity grading Middle
  • Acute toxicity oral-rat LD50: 1540 mg/kg; oral-mouse LD50: 1720 mg/kg
  • Hazardous characteristics of the explosive Explosible when react with butanol, 2,4-dichlorophenol and sodium hydroxide
  • Flammability hazard Flammable in case of heat, open flame; being able to react with oxidant; releasing toxic pungent smoke when in the process of pyrolysis.
  • Storage and transportation properties Make sure ventilating, low temperature and drying in the warehouse; separate from the oxidant; prevent fires.
  • Extinguishing agent Dry powder, carbon dioxide, foam
  • Description Dihydro-2(3H)-furanone. An endogenous neuroregulator made from gamma-amino butyrate and the precursor of gamma hydroxybutyrate. It causes selective increase of brain dopamine by inhibiting its release from nerve terminals. The compound has sedative properties at low doses and produces surgical anesthesia at high doses. It is also used as an industrial solvent and precursor.
  • Chemical Properties γ-Butyrolactone is oily, colorless, clear liquid. It has a faint, sweet, aromatic, slightly buttery odor.
    γ-Butyrolactone is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer.
  • Occurrence Reported found as a constituent in coffee aroma; a volatile flavor component in roasted filberts as well. Also reported found in tomato, potato, soybeans, beans, vinegar, mushrooms, roasted chicken, beef, cider, beer, wine, scallops and clams.
  • Uses r-butyrolactone is one kind of important fine chemicalintermediate, simultaneously also is one kind of performance fine highboiling point solvent, ideal antioxidant, plasticizer,extracting agent, absorbent, dispersing agent, solid stain, Coagulation Reagent.
  • Uses Intermediate in the synthesis of polyvinylpyrrolidone, DL-methionine, piperidine, phenylbutyric acid, thiobutyric acids. Solvent for polyacrylonitrile, cellulose acetate, methyl methacrylate polymers, polystyrene. Constituent of paint removers, textile aids, drilling oils.
  • Definition ChEBI: A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.
  • Preparation From acetylene and formaldehyde, also from a number of alternative sources; ethylene chlorohydrin, glutamic acid, γ-hydroxybutyric acid solutions, tetrahydrofuran, vinyl-acetic acid.
  • Aroma threshold values Detection: 20 to 50 ppm
  • Taste threshold values Taste characteristic at 75 ppm: milky, creamy with fruity peach-like afternotes.
  • General Description Clear colorless oily liquid with a pleasant odor.
  • Air & Water Reactions Hygroscopic. Soluble in water.
  • Reactivity Profile gamma-Butyrolactone can react with oxidizing materials, inorganic acids and bases, alcohols and amines. Rapidly hydrolyzed by bases and slowly hydrolyzed by acids. gamma-Butyrolactone is volatile with steam. . The combination of the lactone, butanol, 2,4-dichlorophenol, and sodium hydroxide in the attempted synthesis of 2,4-dichlorophenoxybutyric acid caused a thermal runaway reaction that eventually exploded, [CISHC Chem. Safety Summ., 1977, 48, 3].
  • Hazard Toxic by ingestion. Questionable carcino- gen.
  • Fire Hazard gamma-Butyrolactone is combustible.
  • Safety Profile Moderately toxic by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data by skin contact. Mutation data reported. Less acutely toxic than ppropiolactone. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. Potentially explosive reaction with butanol + 2,4 dichlorophenol + sodium hydroxide. When heated to decomposition it emits acrid and irritating fumes.
  • Potential Exposure Used as a chemical intermediate for making other chemicals, including pesticides, cosmetics, and pharmaceuticals; as a solvent for paint, nail polish removers, and industrial chemicals. Used in electronics, drilling and petroleum industries as a stabilizer and solvent. Used as a flavoring agent in various foods and beverages, including grains and breakfast foods, candy, and alcoholic and nonalcoholic drinks. Drug of abuse: the United States Food and Drug Administration has warned the public not to purchase or consume products, containing gamma-butyrolactone (GBL). FDA has also asked the companies that manufacture these products to voluntarily recall them. The agency has received reports of serious health problems—some that are potentially life-threatening—associated with the use of these products. Although labeled as dietary supplements and marketed under various brand names, these products are illegally marketed unapproved new drugs. False advertising claims include building muscles, improved physical performance, enhanced sex, reduced stress and induced sleep
  • Shipping Listed by some sources as unregulated. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required.
  • Purification Methods Dry the lactone over anhydrous CaSO4, then fractionally distil it. Handle it in a fume cupboard due to its TOXICITY. [Beilstein 17 V 7.]
  • Incompatibilities 4-Butyrolactone is incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, alcohols, amines, strong and inorganic acids, strong bases. Rapidly hydrolyzed by bases and slowly hydrolyzed by acids. It is hygroscopic and volatile with steam. Combustible; vapor may form explosive mixture with air.
  • Waste Disposal Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. All federal, state, and local environmental regulations must be observed.
Gamma Butyrolactone Preparation Products And Raw materials
Raw materials
Preparation Products
  • Supplier:
  • Tel:8615839353441 86-393-6101536
  • Fax:
  • Country:CHINA
  • ProdList:5
  • Advantage:58
  • Supplier:
    Shanghai UCHEM Inc.
  • Tel:15502138767 15502138767
  • Fax:
  • Country:CHINA
  • ProdList:2773
  • Advantage:58
  • Supplier:
    Shanghai Time Chemicals CO., Ltd.
  • Tel:+8618017249410 +86-021-57951555
  • Fax:+86-021-57951555
  • Country:CHINA
  • ProdList:1365
  • Advantage:55
Related articles
96-48-0, Gamma ButyrolactoneRelated Search:
  • Gamma-Aminobutyric acid(GABA)
  • 4-Hydroxybutyric acid-gama-lactone
  • T-Butyrolactone
  • CadionGr
  • butanolide
  • (g-)bntyrolactone
  • γ-butyrolactone,4-hydroxybutyricacidlactone;tetrahydro-2-furanone
  • r-BUTYROLACTONE extrapure
  • .gamma.-Butyrolacton
  • 2-oxolanone4-butanolide
  • γ-Hydroxybutyric acid lactone, 4-Hydroxybutyric acid lactone, GBL
  • γ-Butyrolactone, γ-Hydroxybutyric acid lactone, 4-Hydroxybutyric acid lactone, GBL
  • 1,4-Lactone
  • -Butyrolactone99.5%
  • 4,5-Dihydrofuran-2(3H)-one
  • Butyrolacyone
  • g-Butyrolactone, synthesis grade
  • gaMMa-Butyrolactone, 99+% 1LT
  • gaMMa-Butyrolactone, Electronic Grade
  • 4-Hydroxybutanoic acid lactone (GBL)
  • gaMMa-Butyrolactone ReagentPlus(R), >=99%
  • 4-Hydroxybutanoic acid lactone, >99.9% (GC)
  • GBL,Gamma-Butyrolactone
  • GBL,γ-BLO
  • γ-Butyrolactone solution
  • <i>γ</i>-Butyrolactone
  • amma-Butyrolactone
  • Gammabutyrolacton (GBL)
  • Natural gamma-Butyrolactone
  • Gamma-Butyrolactone 99.5%
  • γ-Butyrolactone (GBL)
  • 99% Purity Colorless Liquid Gamma-Butyrolactone GBL
  • Gamma-butlrolactione
  • gamma-Butyrolactone GBL CAS: 96-48-0
  • 1-Oxacyclopentan-2-one
  • 2(3H)-dihydrofuranone
  • 2(3H)-Furanone, dihydro-
  • 2(3H)-furanone,dihydro-
  • 2,3,4,5-tetrahydro-2-furanone
  • 2-Oxolanone
  • 2-Oxotetrahydrofuran
  • 3-Hydroxybutyric acid lactone
  • 4,5-dihydro-2(3H)-furanone
  • 4-butanolyde
  • 4-Butonolide
  • 4-Deoxytetronic acid
  • 4-deoxytetronicacid