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4-Phenylbutyric acid

4-Phenylbutyric acid Structure
4-Phenylbutyric acid
  • CAS No.1821-12-1
  • Chemical Name:4-Phenylbutyric acid
  • CBNumber:CB2385237
  • Molecular Formula:C10H12O2
  • Formula Weight:164.2
  • MOL File:1821-12-1.mol
4-Phenylbutyric acid Property
  • Melting point: :49-51 °C(lit.)
  • Boiling point: :165 °C10 mm Hg(lit.)
  • Density  :1.0326 (rough estimate)
  • refractive index  :1.5405 (estimate)
  • Flash point: :>230 °F
  • storage temp.  :Sealed in dry,Room Temperature
  • solubility  :5.3g/l
  • pka :4.76(at 25℃)
  • form  :Crystalline Powder
  • color  :White to slightly yellow
  • Water Solubility  :5.3 g/L at 40 ºC
  • BRN  :638180
  • InChIKey :OBKXEAXTFZPCHS-UHFFFAOYSA-N
  • CAS DataBase Reference :1821-12-1(CAS DataBase Reference)
  • EWG's Food Scores :1
  • FDA UNII :7WY7YBI87E
  • NCI Drug Dictionary :Buphenyl
  • NIST Chemistry Reference :4-Phenylbutanoic acid(1821-12-1)
  • EPA Substance Registry System :4-Phenylbutyric acid (1821-12-1)
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :22-24/25-36-26
  • WGK Germany  :3
  • Hazard Note  :Irritant
  • TSCA  :Yes
  • HS Code  :29163900
  • NFPA 704:
    1
    1 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H315-H319
  • Precautionary statements P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
4-Phenylbutyric acid Price More Price(7)
  • Brand: Sigma-Aldrich
  • Product number: P21005
  • Product name : 4-Phenylbutyric acid
  • Purity: 99%
  • Packaging: 25g
  • Price: $56.5
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: P21005
  • Product name : 4-Phenylbutyric acid
  • Purity: 99%
  • Packaging: 100g
  • Price: $165
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: P0643
  • Product name : 4-Phenylbutyric Acid
  • Purity: >98.0%(GC)(T)
  • Packaging: 25g
  • Price: $53
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: P0643
  • Product name : 4-Phenylbutyric Acid
  • Purity: >98.0%(GC)(T)
  • Packaging: 250g
  • Price: $308
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: A18115
  • Product name : 4-Phenylbutyric acid, 99%
  • Purity: 
  • Packaging: 25g
  • Price: $54
  • Updated: 2021/03/22
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4-Phenylbutyric acid Chemical Properties,Usage,Production

  • Chemical Properties 4-Phenylbutyric acid is white to slightly yellowish crystalline powder
  • Uses A chemical chaperone involved in protein-folding disorders.
  • Uses 4-Phenylbutyric acid is used as organic intermediates.
  • Definition 4-Phenylbutyric acid is a monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apopto is in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
  • Synthesis Reference(s) Tetrahedron Letters, 32, p. 3309, 1991 DOI: 10.1016/S0040-4039(00)92693-5
  • Purification Methods Crystallise the acid from pet ether (b 40-60o). [Beilstein 9 IV 1811.]
4-Phenylbutyric acid Preparation Products And Raw materials
Raw materials
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