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Erythromycin Estolate

Erythromycin Estolate Structure
Erythromycin Estolate
  • CAS No.3521-62-8
  • Chemical Name:Erythromycin Estolate
  • CBNumber:CB1286137
  • Molecular Formula:C52H97NO18S
  • Formula Weight:1056.39
  • MOL File:3521-62-8.mol
Erythromycin Estolate Property
  • Melting point: :135-140°C dec.
  • Boiling point: :743℃
  • Density  :1.0053 (rough estimate)
  • refractive index  :1.6550 (estimate)
  • Flash point: :>110°(230°F)
  • storage temp.  :-20°C Freezer
  • solubility  :chloroform: soluble4.0ML, clear, colorless (200 mg + 4.0 mL Chloroform)
  • pka :6.9(at 25℃)
  • form  :neat
  • color  :white
  • Water Solubility  :Freely soluble in organic solvents, practically insoluble in water /n
  • Sensitive  :Light Sensitive
  • CAS DataBase Reference :3521-62-8
  • FDA UNII :XRJ2P631HP
Safety
  • Hazard Codes  :Xn,Xi
  • Risk Statements  :22-42/43-36/37/38
  • Safety Statements  :22-36-26
  • WGK Germany  :3
  • RTECS  :KF5775000
  • HS Code  :29419000
  • Toxicity :LD50 orally in rats: >5000 mg/kg (Goldenthal)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H317-H334
  • Precautionary statements P280g-P342+P311a-P501a-P261-P280-P342+P311-P284-P301+P312+P330-P304+P340
Erythromycin Estolate Price More Price(3)
  • Brand: Sigma-Aldrich
  • Product number: E1400000
  • Product name : Erythromycin estolate
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: e1400000
  • Price: $183
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1243002
  • Product name : Erythromycin estolate
  • Purity: 
  • Packaging: 200mg
  • Price: $357.7
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J66548
  • Product name : Erythromycin estolate
  • Purity: 
  • Packaging: 5g
  • Price: $160
  • Updated: 2019/12/02
  • Buy: Buy

Erythromycin Estolate Chemical Properties,Usage,Production

  • Chemical Properties Long Needles
  • Uses Macrolides Antibiotics
  • Uses Used as an antibacterial agent. LD50 >5000 mg/kg for oral administration to rats
  • brand name Antibio-aberel;Apo-erythro-s;Bio-exazol;Biometran;Biomicron;Chemthromycin;Cimetrin;Cusimicina balsamica;Doboiosol;Dowmicyn;Dreimicina;Duozplin vitaminado;Dynabiotal;Ees-200;Ees-400;E-mycine;Endoeritrina;Erimec;Erirobios;Eritrazol;Eritrobios;Eritrobiotic;Eritrocin;Eritrodes;Eritronicol;Eritropan;Eritroveinte;Eritrovienite;Eritrowolf;Eritro-wolf;Erymycin;Eryped;Ery-tar;Erythromictine;Erythro-prat;Ery-toxinal;Erytrodol;Erytro-prot;Eryt-toxinal;Espimina;Estimina;Estomiicina;Estomycin;Fesmicina;Ilosone pulvules;Ilosone ready-mix;Ilothycin;Kesso-mycin;Laucetin;Laurilin;Lauritran;Liferitrin;Loderm;Lubomycina;Lubomycine;Makrocyklina;Manilina;Marocid;Neo-ilolycina;Neo-iloticina;Niux;Novorythro;Propriocin enfante;Prospiocine;Proterytrin;Pulmomas;Purmycin;Ritromin;Roxo chemil;Roxochemil;Rp-mycin;Rubibacter;Selvicin;Spetrasone;Stella micina;Taimoxin;Togerin;Togrien;Tosinova;Tropoxin;Wyamycin s.
  • World Health Organization (WHO) Erythromycin estolate, a macrolide antibiotic, was introduced in 1958 for the treatment of gram-positive infections. By the early 1970s its use had been associated with a higher incidence of hepatic toxicity than that seen with other salts and esters of erythromycin. This led to its withdrawal by some regulatory authorities whereas others required the addition of a warning in the product information. Evidence that the estolate ester is more hepatotoxic than other salts or esters has subsequently been disputed. It has been claimed to be the most effective ester for treatment of Legionnaire's disease and preparations remain widely available. (Reference: (BMJOAE) British Medical Journal, 286, 1954, 1983)
  • General Description Erythromycin estolate, erythromycin propionate lauryl sulfate(Ilosone), is the lauryl sulfate salt of the 2＇-propionateester of erythromycin. Erythromycin estolate is acid stableand absorbed as the propionate ester. The ester undergoesslow hydrolysis in vivo. Only the free base binds to bacterialribosomes. Some evidence, however, suggests that theester is taken up by bacterial cells more rapidly than thefree base and undergoes hydrolysis by bacterial esteraseswithin the cells. The incidence of cholestatic hepatitis is reportedlyhigher with the estolate than with other erythromycinpreparations.
    Erythromycin estolate occurs as long needles that aresparingly soluble in water but soluble in organic solvents. administration for the treatment of serious infections,such as Legionnaires disease, or when oral administrationis not possible. Solutions are stable for 1 week whenrefrigerated.
Erythromycin Estolate Preparation Products And Raw materials
Raw materials
Preparation Products
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3521-62-8, Erythromycin EstolateRelated Search:
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  • neo-erycinum
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  • Phtalic anhydride
  • [4-Dimethylamino-2-[[(3R,4S,6R,7R,9R,11R,12R,13R,14R)-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradec-6-yl]oxy]-6-methyl-oxan-3-yl] propanoate 1-sulfooxydodecane
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  • Eriscel
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  • Sulfuric acid, monododecyl ester, compd. with erythromycin 2'-propionate (1:1) (8CI)
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  • ERYTHROMYCINPROPIONATELAURYLSULPHATE
  • 3521-62-8
  • C40H71NO14C12H26O4S
  • C40H71NO14C12H26SO4
  • C52H97NO18S