Description
Z-
FA-
FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain. It also inhibits effector caspases-
2, -
3, -
6, and -
7 (IC
50 = 6-
32 μM) without affecting the initiator caspases-
8 and -
10. Z-
FA-
FMK also modulates infection by certain bacteria, parasites, and viruses. It can be used both in cells and
in vivo.
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] FRANCISCO J LOPEZ-HERNANDEZ. Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathway.[J]. Molecular Cancer Therapeutics, 2003, 2 3: 255-263.
[3] GUENTER HARTH . Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi[J]. Molecular and biochemical parasitology, 1993, 58 1: Pages 17-24. DOI:
10.1016/0166-6851(93)90086-d[4] CLARE P LAWRENCE. The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo.[J]. Journal of immunology, 2006, 177 6: 3827-3836. DOI:
10.4049/jimmunol.177.6.3827[5] MANBOK KIM. Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo.[J]. Antiviral Therapy, 2010, 15 6: 897-905. DOI:
10.3851/imp1646
