| Name | Z-FA-FMK |
| Description | Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases. |
| Cell Research | T cell proliferation following mitogen stimulation is determined using [3H]thymidine incorporation. In brief, PBMCs or purified T cells are seeded in a 96-well plate and stimulated with either PHA (5 μg/ml), costimulated with anti-CD3 mAb (5 μg/ml) and anti-CD28 mAb (2.5 μg/ml) or PMA plus ionomycin in the presence or absence of z-FA-FMK. The cells are cultured for 72 h with the last 16 h pulsed with [methyl-3H]thymidine (0.037 MBq). The cells are harvested onto glass fiber filter mats using a Tomtec automated multiwell harvester. (Only for Reference) |
| In vitro | Z-FA-FMK inhibits the development of Ras-induced carcinogenic tumors and respiratory viral infections in the cardiac tissue of mice with severe combined immunodeficiency (SCID). In a mouse model of intranasal pneumococcal infection, Z-FA-FMK significantly promotes the growth of Streptococcus pneumoniae in both the lungs and the bloodstream. |
| In vivo | Z-FA-FMK effectively inhibits T-cell proliferation induced by interleukin-2 (IL-2) and mitogens in vitro. It also prevents the degradation of fibrillar collagen through its actions on fibroblasts and osteoclasts. Furthermore, Z-FA-FMK suppresses the expression of NF-κB-dependent genes in macrophages, thereby inhibiting the production of cytokines induced by lipopolysaccharides. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 71 mg/mL (183.7 mM)
Ethanol : 32 mg/mL (82.8 mM)
|
| Keywords | SARS coronavirus | SARS-CoV | RRMs | DNA fragmentation | DEVDase | Caspase | Cathepsin | Inhibitor | externalization of phosphatidylserine | Apoptosis | inhibit | Z FA FMK | reovirus replication | Z-FA-FMK | ZFAFMK |
| Inhibitors Related | Papain | Nirmatrelvir | 2-Aminoethanethiol | EIDD-1931 | (S)-(+)-Ibuprofen | Remdesivir | Silymarin | Umifenovir hydrochloride | Hydroxychloroquine | Ritonavir | Chloroquine phosphate | Favipiravir |
| Related Compound Libraries | Highly Selective Inhibitor Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Protease Inhibitor Library | Anti-Viral Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Human Metabolite Library |
United States
