197855-65-5

Z-FA-FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain. It also inhibits effector caspases-2, -3, -6, and -7 (IC₅₀ = 6-32 μM) without affecting the initiator caspases-8 and -10. Z-FA-FMK also modulates infection by certain bacteria, parasites, and viruses. It can be used both in cells and in vivo.

Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain.

Cathepsin B; cathepsin L; Caspase-2; Caspase-3; Caspase-6; Caspase-7

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