Uses
Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase
Uses
N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.
Definition
ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde.
It is an inhibitor of caspase-3/7.
General Description
N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.
Biochem/physiol Actions
N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.
