Chemical Properties
White crystals, soluble in methanol, ethanol, and DMSO, derived from the dried roots of Cyathula officinalis Kuan.
Uses
Cyasterone is a phytoecdysteroid that has been shown to prevent the hepatotoxic action of CCl4 when administered to rats with hepatitis.
Definition
ChEBI: Cyasterone is a steroid lactone, a 21-hydroxy steroid, a 2beta-hydroxy steroid, a 3beta-hydroxy steroid, a 14alpha-hydroxy steroid, a 20-hydroxy steroid, a 6-oxo steroid and a phytoecdysteroid.
in vivo
Cyasterone (intraperitoneal injection; 5 mg/kg, 10 mg/kg and 15 mg/kg; 21 days) has anti-proliferation effect in vivo and inhibits MGC823 cells xenografted tumor growth in vivo with few changes in body weights[2].
| Animal Model: | MGC823 xenograft tumor in BALB/C-nu mice[1] |
| Dosage: | 5 mg/kg, 10 mg/kg and 15 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Inhibited MGC823 xenograft tumor growth in vivo. |
