Names
Name cyasterone
Synonym More Synonyms
Cyasterone Biological Activity
Description Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae).Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a clinical therapeutic anti-tumor agent against human tumors[1].
Related Catalog
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
In Vitro Cyasterone (0-100μM; 24hours) inhibits cell growth in a concentration-and time-dependent manner, IC50 values are 38.50 mg/mL, 32.96 mg/mL in A549 and MGC823 cells ,respectively[1]. Cell Viability Assay[1] Cell Line: A549, HCT116, MGC823 cells Concentration: 0-100 μM Incubation Time: 24 hours Result: Inhibited the growth of 3 human cancer lines A549, HCT116, MGC823 cells.
References
[1]. Lu X, et al. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother. 2016 Dec;84:330-339.
Chemical & Physical Properties
Density 1.3±0.1 g/cm3
Boiling Point 742.8±60.0 °C at 760 mmHg
Molecular Formula C29H44O8
Molecular Weight 520.655
Flash Point 242.0±26.4 °C
Exact Mass 520.303589
PSA 144.52000
LogP -0.25
Vapour Pressure 0.0±5.6 mmHg at 25°C
Index of Refraction 1.600
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
WJ2510000
CHEMICAL NAME :
5-beta-Stigmast-7-en-26-oic acid, 2-beta,3-beta,14,20,22,28-hexahydroxy-6-oxo-, gamma- lactone, (22R,24S,25S,28R)-
CAS REGISTRY NUMBER :
17086-76-9
LAST UPDATED :
198909
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C29-H44-O8
MOLECULAR WEIGHT :
520.73
WISWESSER LINE NOTATION :
L E5 B666 LV JUTJ IQ OQ PQ FXQ1&YQ1YYQ1&Y1&- CT4OVTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
TEST SYSTEM :
Insect - Drosophila melanogaster
DOSE/DURATION :
300 umol/L
REFERENCE :
NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246, 1971-73. For publisher information, see NATUAS. Volume(issue)/page/year: 230,222,1971
Safety Information
Safety Phrases 24/25
RIDADR NONH for all modes of transport
RTECS WJ2510000
Synonyms
China
