Chemical Properties
N-Ethyl-2-pyrrolidone (NEP) is a colorless, clear liquid that serves as a low-volatility aprotic solvent classified as a reproductive toxicant. It is characterized by high solvency, low vapor pressure, and a low dielectric constant.
Uses
1-Ethyl-2-pyrrolidone was used to modify coir fiber (from
Cocos nucifera) by photocuring.
Application
N-Ethyl-2-pyrrolidone is commonly used as a solvent. It has a low boiling point, which makes it suitable for use in low light and at constant pressure. It is also used as an intermediate in the preparation of polycarboxylic acid. It has been shown to be involved in both viscosity and hydrogen bonding.
Definition
ChEBI: 1-Ethyl-2-pyrrolidinone is a N-alkylpyrrolidine.
General Description
1-Ethyl-2-pyrrolidone is a transdermal absorption-enhancing compound and mechanism of its effect on multilammellar liposome of stratum corneum lipid has been studied.
Flammability and Explosibility
Non flammable
Biological Activity
CDK7 gene is a member of the cyclin-dependent protein kinase family th at is important regulators of cell cycle progression. CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH th at is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle.
Side effects
Neurotoxins - Acute Solvent Syndrome
Occupational Hepatotoxin - Secondary Hepatotoxin: Cases of possible toxic effects in an occupational setting depending on human ingestion or experimental poisoning of animals.
Reproductive toxin - A chemical that is toxic to the reproductive system, including offspring defects and damage to male or female reproductive function. Reproductive toxicity includes developmental effects.
Safety Profile
Moderately toxic by
ingestion. An eye irritant. Combustible.
When heated to decomposition it emits
toxic fumes of NOx.
Toxics Screening Level
The initial threshold screening level (ITSL) for 1-ethyl-2-pyrrolidone (CAS # 2687-91-4) is 4.9 μg/m3 based on an annual averaging time.
