Chemical Properties
Pale yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the rhizomes of Sinopodophyllum hexandrum (Royle) Ying; Dysosma versipellis (Hance) M. Cheng ex Ying.
Uses
Diphyllin has been used to study its antibacterial and antibiofilm activities against fish pathogens.
Definition
ChEBI: Diphyllin is a lignan.
General Description
Diphyllin, a major glycoside compound, is a plant-derived lignan. It is present in
Cleistanthus collinus.
Biochem/physiol Actions
Diphyllin is a natural arylnaphthalene that exhibits potent anticancer and antiviral activities. It is a potent inhibitor of vacuolar H(+)-ATPase (V-ATPase) that inhibits lysosomal acidification in osteoclasts.
in vivo
Diphyllin (20 mg/kg; oral; once a day; for 10 consecutive days) significantly inhibits the tumor growth of SGC7901 cells in mice, reduced tumor weight, downregulated the expression of V-ATPase in tumor tissues, and reduced the levels of MMP-2 and MMP-9 in serum[4].
IC 50
HIV-1: 0.38 μM (IC
50); Vacuolar type H
+-ATPase: 17 nM (IC
50); Vesicular stomatitis virus (VSV)
