Description
PAPA NONOate (146672-58-4) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of PAPA NONOate in 0.1 M phosphate buffer at pH 7.4 is 15 minutes at 37°C, or 77 minutes at room temperature.1Dissociation is essentially instantaneous at a pH of 5.0.
Uses
PAPA NONOate is an NO donor which suppresses the caspase apoptotic cascade.
Definition
ChEBI: PAPA NONOate is an alkylamine.
in vivo
PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2].
| Animal Model: | Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2] |
| Dosage: | 100 μM |
| Administration: | Wounds received 100 μM PAPA NONOate in phosphate buffer |
| Result: | Increased the wound healing rate in test group.
|
References
[1] L K KEEFER. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms.[J]. Methods in enzymology, 1996, 268: 281-293. DOI:
10.1016/s0076-6879(96)68030-6
