Description
NOC-
5 is a stable nitric oxide (NO)-
amine complex that acts as a NO donor. It can release two equivalents of NO in solution under physiological conditions without a cofactor. The half-
life of NOC-
5 in PBS (pH 7.4) is 93 minutes at 22°C, and it remains relatively stable in alkaline solution (pH ≥10.0).
Chemical Properties
White Powder
Uses
Releases nitric oxide spontaneously in a rate-controlled manner; half life in solution = 93 min.
Uses
A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37C for 0.1mM NOC 5 is 25 minutes.
Definition
ChEBI: NOC-5 is a nitroso compound that is triazane in which the nitrogen at position 1 is substituted by an isopropyl group and a 3-aminopropyl group, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group. It is a nitric oxide donor. It has a role as a nitric oxide donor. It is a nitroso compound, a tertiary amino compound and a primary amino compound.
References
[1] JOSEPH A. HRABIE. New nitric oxide-releasing zwitterions derived from polyamines[J]. The Journal of Organic Chemistry, 1993, 58 6: 1472-1476. DOI:
10.1021/jo00058a030
