Description
MAHMA NONOate is a NO donor. It spontaneously dissociates in a pH-
dependent, first-
order process with a half-
life of 1 minute and 3 minutes at 37°C and 22-
25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.
Chemical Properties
white to off-white crystalline solid
Uses
MAHMA NONOate is a diazeniumdiolate quick-releasing NO donor.
in vivo
MAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo[2].
| Animal Model: | Male Wistar rats anaesthetised with pentobarbitone[2] |
| Dosage: | 0.3-10 nmol/kg/min |
| Administration: | Intravenous injection; 0.3-10 nmol/kg/min once |
| Result: | Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.
|
References
[1] L K KEEFER. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms.[J]. Methods in enzymology, 1996, 268: 281-293. DOI:
10.1016/s0076-6879(96)68030-6[2] TENG LI. Rational Design and Bioimaging Applications of Highly Specific “Turn-On” Fluorescent Probe for Hypochlorite[J]. Bioconjugate Chemistry Bioconjugate, 2018, 29 8: 2838-2845. DOI:
10.1021/acs.bioconjchem.8b00430
