Description
1,2-Dioleoyl-
sn-glycero-3-PS (DOPS) is a phospholipid containing oleic acid (Item Nos.
90260 |
24659) at the
sn-1 and
sn-2 positions, respectively. Nanovesicles composed of DOPS and the lysosomal protein saposin C (SapC) are cytotoxic to SK-MEL-28 cells
in vitro and decrease tumor volume in a squamous cell carcinoma mouse xenograft model. DOPS has been used in the formation of unilamellar vesicles to study the effect of curvature on membrane structure and in the formation of supported lipid bilayers to study the effects of various support materials on lipid redistribution between membrane leaflets.
Uses
1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) is a lipid being studied in the assembly and long-term stability of solid supported lipid bilayers from artificial and natural lipid mixtures.
References
[1] SHADI ABU-BAKER. Cytotoxicity and Selectivity in Skin Cancer by SapC-DOPS Nanovesicles.[J]. Journal of Cancer Therapy, 2012, 3 4: 321-326. DOI:
10.4236/jct.2012.34041[2] NORBERT KUERKA. Curvature Effect on the Structure of Phospholipid Bilayers[J]. Langmuir, 2006, 23 3: 1292-1299. DOI:
10.1021/la062455t[3] RALF P. RICHTER Alain R B Nicolas Maury. On the Effect of the Solid Support on the Interleaflet Distribution of Lipids in Supported Lipid Bilayers[J]. Langmuir, 2004, 21 1: 299-304. DOI:
10.1021/la0478402
