1,4-DIMETHYLNAPHTHALENE

Uses

1,4-Dimethylnaphthalene is a polycyclic aromatic hydrocarbon (PAH) that has been found in dust particulate matter and is associated with activation of aryl hydrocarbon receptor as a major toxic mode of action in WB-F344 cell line. 1,4-Dimethylnaphthalene has been found to retard the development of epidermoid carcinomas in hamster buccal pouch. 1,4-Dimethylnaphthalene alters the genes associated with the maintenance of a G1/S phase block possibly through the induction of the cell cycle inhibitors KRP1 and KRP2 in potatoes.

Definition

ChEBI: A dimethylnaphthalene carrying methyl groups at positions 1 and 4.

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 1251, 1981 DOI: 10.1021/jo00320a005