Chemical Properties
Off-White Solid
moderately soluble in water
Originator
Marezine,BurroughsWellcome,US,1953
Uses
Motion sickness (prophylaxis and treatment)—Oral cyclizine is indicated for the prophylaxis and treatment of nausea, vomiting, and dizziness associated with motion sickness.
Nausea and vomiting, postoperative (prophylaxis and treatment)—to prevent or reli
Uses
Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.
Definition
ChEBI: Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist and an antiemetic. It contains a cyclizine.
Manufacturing Process
One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g)
of N-methylpiperazine and about 10 cc of benzene and the whole was heated
on the steam bath four hours. The contents of the flask was partitioned
between ether and water, and the ethereal layer was washed with water until
the washings were neutral. The base was then extracted from the ethereal
layer by N hydrochloric acid and the extract, made acid to Congo red paper,
was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by
recrystallization from 95% alcohol melting above 250°C with decomposition.
The addition of alkali to an aqueous solution of the dihydrochloride liberated
the base which was recovered by recrystallization from petroleum ether
melting at 105.5° to 107.5°C.
Therapeutic Function
Antinauseant
