Uses
N-Ethylthiourea was used in the preparation of Re (III) complexes, which are precursors for the new rhenium complexes, potentially useful in nuclear medicine. It was also used in two-step protocol for the first chemoselective cleavage of 2-hydroxy acid amides
Definition
ChEBI: N-ethylthiourea is a member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by an ethyl group. It is functionally related to a thiourea.
General Description
N-Ethylthiourea forms adduct with silver halides and their single crystal X-ray structural and spectroscopic characterizations are described.
Biological Activity
Potent, selective and reversible inhibitor of isoform II NO synthase (IC 50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).
Safety Profile
Poison by ingestion.
SYN: 1-ETHYLTHIOUREA
Experimental teratogenic effects. Mutation
data reported. When heated to decomposition it emits toxic fumes of Sox and NOx.
Purification Methods
Crystallise the thiourea from EtOH, MeOH or ether. [Beilstein 4 IV 374.]
