Uses
nicotinyl acetylchloline receptor agonist, ectoparasiticide
General Description
Potent agonist of the nicotinic acetylcholine receptor. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions.
Biological Activity
Nicotinic acetylcholine receptor (nAChR) agonist (K i values are 1, > 1000, 4000 and 7130 nM at α 4 β 2, α 1 β 1 δ γ , rat α 7 and human α 7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo .
Biochem/physiol Actions
Product does not compete with ATP.
Safety Profile
Poison by ingestion,
intravenous, intraperitoneal, and
subcutaneous routes. An experimental
teratogen. Experimental reproductive
effects. When heated to decomposition it
emits toxic fumes of NOx and CO. See also
NICOTINE.