4',7-Dimethoxy-3,3',5-trihydroxyflavone

Uses

Ombuin is a synthetic flavonoid which displays activity as a potent mycobacterium tuberculosis inhibitor.

Definition

ChEBI: Ombuin is a dimethoxyflavone that is quercetin in which the hydroxy groups at positions 7 and 4' are replaced by methoxy groups. Isolated from Cyperus teneriffae, it exhibits anti-inflammatory activity. It has a role as an anti-inflammatory agent and a plant metabolite. It is a trihydroxyflavone, a member of flavonols and a dimethoxyflavone. It is functionally related to a quercetin. It is a conjugate acid of a 7,4'-O-dimethylquercetin 3-olate.

References

[1] FAZILATUN NESSA . Free radical-scavenging activity of organic extracts and of pure flavonoids of Blumea balsamifera DC leaves[J]. Food Chemistry, 2004, 88 2: Pages 243-252. DOI: 10.1016/j.foodchem.2004.01.041
[2] MEYYAMMAI SWAMINATHAN. Flavonoids with M1 muscarinic acetylcholine receptor binding activity.[J]. Molecules, 2014, 19 7: 8933-8948. DOI: 10.3390/molecules19078933
[3] D. T. HUONG. A New Flavone and Cytotoxic Activity of Flavonoid Constituents Isolated from Miliusa balansae (Annonaceae).[J]. ChemInform, 2005, 36 50. DOI: 10.1002/chin.200550192
[4] BIN LIU  Ping T  Caichun Deng. Ombuin ameliorates diabetic nephropathy in rats by anti-inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways[J]. Drug Development Research, 2022, 83 6: 1270-1280. DOI: 10.1002/ddr.21956