| Name | Ombuin |
| Description | Ombuin has anti-inflammatory activity, it inhibits some macrophage functions involved in the inflammatory process. |
| In vitro | Compounds 1-7 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose-dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. The concentration causing a 50% inhibition (IC50) of NO, TNF-alpha and IL-12 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 microM, respectively, while at 50, 200 and 40 microM compounds 3, 4, and 5, 6 showed 15-30% inhibition, respectively. On the other hand, compounds 3 and 7 showed no inhibitory effect, while compounds 1, 4-6 reduced by around 10-30% the synthesis of NO by macrophages, when inducible NO synthase was already expressed with LPS/IFN-gamma for 24 h[1] |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (181.66 mM), Sonication is recommended.
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| Keywords | Zanthoxylum | TNF-α | spectrum | Ombuin | NO Synthase | Inhibitor | inhibit | IL Receptor | broad | Bacterial | armatum | antibacterial |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Ampicillin sodium | Acetic Acid | Doxycycline (hyclate) | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Copper(Ⅱ) Sulfate | Doxycycline | Trisodium Phosphate | BES |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Food as Medicine Compound Library |
United States
