Chemical Properties
clear colorless liquid
Uses
N,N-Diethylacetamide was used to investigate the spectroscopic properties ofN,N-diethyl-2-[(4-substituted)phenylsulfinyl] acetamides. It is commonly used as drug solvent.
Synthesis Reference(s)
Chemistry Letters, 18, p. 1983, 1989
The Journal of Organic Chemistry, 59, p. 4035, 1994
DOI: 10.1021/jo00094a004
General Description
N,N-Diethylacetamide is commonly used as drug solvent.
Hazard
Toxic by ingestion.
Safety Profile
Moderately toxic by
ingestion and intraperitoneal routes.
Questionable carcinogen with experimental
tumorigenic data. Flammable when exposed
to heat or flame. To fight fire, use foam,
mist, CO2, dry chemical. When heated to
decomposition it emits toxic fumes of NOx.
Purification Methods
Dissolve the amide in cyclohexane, shake with anhydrous BaO and then filter. The procedure is repeated three times, and the cyclohexane is distilled off at atmospheric pressure. The crude amide is also fractionally distilled three times from anhydrous BaO. [Beilstein 4 III 349.]
