Description
Calenduloside E (CE), a natural pentacyclic triterpenoid saponin, is a significant component of saponin isolated from the bark and root of Aralia elata (Miq.) AS are usually used as an antihypertensive, anti-arrhythmic and anti-diabetic agent in traditional Chinese medicine (Wang et al. 2014). In human umbilical vein endothelial cells (HUVECs), CE and CE analog can repress ox-LDL induced apoptosis (Tian et al. 2019).
References
[1] JIANXIONG LI. Calenduloside E alleviates cerebral ischemia/reperfusion injury by preserving mitochondrial function[J]. Journal of Molecular Histology, 2022, 53 4: 713-727. DOI:
10.1007/s10735-022-10087-5.
[2] YIFEI LE . Calenduloside E ameliorates non-alcoholic fatty liver disease via modulating a pyroptosis-dependent pathway.[J]. Journal of ethnopharmacology, 2023, 319: Article 117239. DOI:
10.1016/j.jep.2023.117239.
[3] LANFANG LI . Calenduloside e modulates macrophage polarization via KLF2-regulated glycolysis, contributing to attenuates atherosclerosis[J]. International immunopharmacology, 2023, 117: Article 109730. DOI:
10.1016/j.intimp.2023.109730.
[4] RUIYING WANG . Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia/reperfusion injury[J]. Journal of Advanced Research, 2021, 34: Pages 173-186. DOI:10.1016/j.jare.2020.10.005.
[5] MIN WANG. Calenduloside E Ameliorates Myocardial Ischemia-Reperfusion Injury through Regulation of AMPK and Mitochondrial OPA1.[J]. Oxidative Medicine and Cellular Longevity, 2020: 2415269. DOI:10.1155/2020/2415269.
