Artemether

Product NameArtemether

CAS71963-77-4

CBNumberCB4248286

MFC16H26O5

MW298.37

EINECS663-549-0

MDL NumberMFCD00866205

MOL File71963-77-4.mol

MSDS FileSDS

Chemical Properties

Melting point	86-88°C
alpha	D19.5 +171° (c = 2.59 in CHCl3)
Boiling point	359.79°C (rough estimate)
Density	1.0733 (rough estimate)
refractive index	1.6200 (estimate)
storage temp.	room temp
solubility	DMSO: ≥20mg/mL
form	powder
color	off-white to light brown
optical activity	[α]/D +155 to +175°, c = 0.5 in methanol
Merck	14,815

Safety

Symbol(GHS)
Signal word	Danger
Hazard statements	H242-H302
Precautionary statements	P210-P235-P280-P301+P312-P370+P378-P410
Hazard Codes	Xn
Risk Statements	22
Safety Statements	24/25
WGK Germany	3
RTECS	KD4165000
HS Code	29329930
Hazardous Substances Data	71963-77-4(Hazardous Substances Data)
Toxicity	LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu)

Artemether Price

Product number	Packaging	Price	Buy
Sigma-Aldrich A9361	5mg	$82.9	Buy
Sigma-Aldrich PHR3423	200MG	$193	Buy
Sigma-Aldrich 1042780	100mg	$400	Buy
TCI Chemical A2190	5g	$76	Buy
TCI Chemical A2190	25g	$225	Buy

Artemether Chemical Properties,Usage,Production

Description
Artemether is an antiparasitic compound and a derivative of artemisinin (Item No. 11816). It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC₅₀s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD₅₀) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.
Chemical Properties
White Solid
Uses
Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when
Uses
atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist
Uses
Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.
Definition
ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria.
General Description
Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant.
Biochem/physiol Actions
Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.
Safety Profile
Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.

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