Artemether is an antiparasitic compound and a derivative of artemisinin (Item No.
11816).
1 It induces mortality in adult wild-type and
pfatp6-mutant
P. falciparum but the efficacy is decreased in the mutants (IC
50s = 8.2 and 13.5 nM, respectively).
2 Artemether reduces parasitemia in
P. falciparum-infected monkeys and
P. berghei-infected mice with 50% curative dose (CD
50) values of 7.1 and 55 mg/kg, respectively.
3 It also reduces the worm burden of
S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg.
1 Formulations containing artemether have been used in the treatment of malaria.
