26020-14-4

Calenduloside E (CE), a natural pentacyclic triterpenoid saponin, is a significant component of saponin isolated from the bark and root of Aralia elata (Miq.) ?AS are usually used as an antihypertensive, anti-arrhythmic and anti-diabetic agent in traditional Chinese medicine (Wang et al. 2014). In human umbilical vein endothelial cells (HUVECs), CE and CE analog can repress ox-LDL induced apoptosis (Tian et al. 2019).

Oleanolic Acid 3-O-Glucuronide exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by inhibiting glucose transport at the brush border of the small intestine in oral glucose-loaded rats.

ChEBI: Oleanolic acid 3-O-beta-D-glucosiduronic acid is a beta-D-glucosiduronic acid. It is functionally related to an oleanolic acid.

[1] JIANXIONG LI. Calenduloside E alleviates cerebral ischemia/reperfusion injury by preserving mitochondrial function[J]. Journal of Molecular Histology, 2022, 53 4: 713-727. DOI:10.1007/s10735-022-10087-5.
[2] YIFEI LE . Calenduloside E ameliorates non-alcoholic fatty liver disease via modulating a pyroptosis-dependent pathway.[J]. Journal of ethnopharmacology, 2023, 319: Article 117239. DOI:10.1016/j.jep.2023.117239.
[3] LANFANG LI . Calenduloside e modulates macrophage polarization via KLF2-regulated glycolysis, contributing to attenuates atherosclerosis[J]. International immunopharmacology, 2023, 117: Article 109730. DOI:10.1016/j.intimp.2023.109730.
[4] RUIYING WANG . Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia/reperfusion injury[J]. Journal of Advanced Research, 2021, 34: Pages 173-186. DOI:10.1016/j.jare.2020.10.005.
[5] MIN WANG. Calenduloside E Ameliorates Myocardial Ischemia-Reperfusion Injury through Regulation of AMPK and Mitochondrial OPA1.[J]. Oxidative Medicine and Cellular Longevity, 2020: 2415269. DOI:10.1155/2020/2415269.