Chemical Properties
Lump powder; Vapour pressure of 1,3,5-tribromobenzene between 295 and 389 K (solid) and 397 and 410 K (liquid). The enthalpies of sublimation and vaporisation were derived from the relationship between vapour pressure and temperature: ΔH°SUB(334.78 K) = 83.54 ± 2 kJ/mol and ΔH°vap(403.23 K) = 58.68 ± 1.5 kJ/mol.
Uses
Intermediate in drug manufacturing; organic synthesis; internal standard in analysis of
aqueous samples.
Uses
1,3,5-Tribromobenzene, is a reagent that can be used in the preparation of different inhibitors. It is also a substituted Bromobenzene, a general reagent in palladium-catalyzed reactions and in the synthesis of Grignard reagents.
General Description
- 1,3,5-Tribromobenzene(TBB) acts as internal standard during derivatization step in determination of cyanide in human plasma and urine by gas chromatography-mass spectrometry.
- TBB forms molecular complexes of 1:2 stoichiometry with [60]-and [70] fullerenes.
- TBB reacts with perfluoroalkenylzinc reagent in the presence of Pd(Ph3)4 catalyst to yield a novel trifunctional monomer 1,3,5-tris(α, β, β-trifluorovinyl)benzene.
Environmental Fate
Photolytic. Peijnenburg et al. (1992) investigated the photodegradation of a variety of
substituted aromatic halides using a Rayonet RPR-208 photoreactor equipped with 8 RUL 3,000-
? lamps (250–350 nm). The reaction of 1,3,5-tribromobenzene (initial concentration 10-5 M) was
conducted in distilled water and maintained at 20 °C. Though no products were identified, the
investigators reported photohydrolysis was the dominant transformation process. The measured
pseudo-first-order reaction rate constant and corresponding half-life were 0.005/min and 140.5
min., respectively.
Chemical/Physical. 1,3,5-Tribromobenzene will not hydrolyze to any reasonable extent.
Purification Methods
Crystallise it from glacial acetic acid/water (4:1), then wash with chilled EtOH and dry in air. [Beilstein 5 H 213, 5 IV 685.]
