Uses
Ro 04-6790 is a SR-6 antagonist.
Definition
ChEBI: 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide is a sulfonamide and a member of benzenes.
Biological Activity
Potent and selective 5-HT 6 receptor antagonist (pK i values are 7.26 and 7.35 at rat and human 5-HT 6 receptors respectively). Displays no affinity at a range of other receptors (IC 50 > 10 μ M). Induces stretching behavior in rats in vivo .
in vivo
Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)[2].
IC 50
Rat 5-HT
6 Receptor: 7.26 (pKi); Human 5-HT
6 Receptor: 7.35 (pKi)
