2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL

Uses

tBuXPhos [2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. tBuXPhos has been used in the preparation of [tBuXPhosAu(MeCN)]BAr4F, a gold catalyst for the intermolecular [2+2] cycloaddition of terminal arylalkynes with substituted alkenes to form functionalized cyclobutenes with high regioselectivity.
tBuXPhos is a ligand for Pd-catalyzed C-O and C-N bond formation.
It can be used in the following reactions:
• Palladium-catalyzed Tsuji-Trost substitution and cross-coupling of benzylic fluorides.
• Palladium-catalyzed C-N cross-coupling of sulfinamides and aryl halides.
• Palladium-catalyzed rapid methoxylation and deuteriomethoxylation of bromo-chalcones.

Reactions

• Effective ligand for the Pd-catalyzed arylation of pyrazoles, indazoles and amino heterocycles.
• Ligand used in the Pd-catalyzed synthesis of phenols from aryl halides and KOH.
• Ligand used in the Pd-catalyzed of benzoic acids from aryl halides and CO2.
• Ligand used in the Pd-catalyzed trifluoromethylation of vinyl sulfonates.
• Ligand used in the Pd-catalyzed arylation of nitroacetates.
• Ligand used in the Pd-catalyzed Suzuki−Miyaura cross-coupling of allylboronates and aryl halides.
• Ligand used in the Pd-catalyzed cyanation of (hetero)arylchlorides and bromides.
• Ligand used in the Pd-catalyzed C–N cross coupling of sulfinamides and aryl halides.
• Ligand used in the Pd-catalyzed arylation of cyanamides. 

 

Chemical Properties

White to pale yellow

Uses

suzuki reaction

Uses

tBuXPhos is a ligand for Pd-catalyzed C-O and C-N bond formation.
It can be used in the following reactions:

• Palladium-catalyzed Tsuji-Trost substitution and cross-coupling of benzylic fluorides.
• Palladium-catalyzed C-N cross-coupling of sulfinamides and aryl halides.
• Palladium-catalyzed rapid methoxylation and deuteriomethoxylation of bromo-chalcones.

Uses

Effective ligand for the Pd-catalyzed arylation of pyrazoles, indazoles and amino heterocycles

General Description

tBuXPhos [2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.