3-Amino-5-phenylpyrazole

Chemical Properties

Off-white to cream colored crystalline powder

Uses

3-Amino-5-phenylpyrazole ((3-phenyl-1H-pyrazol-5-amine) may be used in the synthesis of the following:

• Urea derivatives by reaction with azido(6-(benzofuran-2-yl)-2-methylpyridin-3-yl) methanone.
• 2-Mercaptoacetamide analogs by treating with thioglycolic acid.
• 3-(Substituentpyrimidayl)-5,6-benzocoumarins by treating with 3-(2′-formyl-1′-chlorovinyl)-5,6-benzocoumarin.
• Substituted 2,7-diphenylpyrazolo[1,5-a]pyrimidine-5-carboxylic esters by reacting with substituted β-diketo esters.
• N-ethoxycarbonylthiourea derivative by reacting with ethoxycarbonyl isothiocyanate.
• Heterobiaryl pyrazolo[3,4-b]pyridines by reacting with indole-3-carboxaldehyde.

General Description

3-Amino-5-phenylpyrazole (3-phenyl-1H-pyrazol-5-amine), an amino pyrazole derivative, is an aza-heterocyclic amine. It has been reported to be synthesized by heating either 3-amino-4-bromo- or 3-amino-5-phenylisothiazole in the presence of anhydrous hydrazine. On reaction with ZnCl₂ it affords chlorido-tris(3-amino-5-phenyl-1Hpyrazole-N²)zinc (II) chloride.