Chemical Properties
SLIGHTLY YELLOW TO BEIGE CRYSTALLINE POWDER
Uses
2-Aminopyrazine acts as a raw material in a four-component synthesis of imidazolidines. It is also used as an intermediate in synthetic chemistry. In addition, 2-aminopyrazine can be reacted with α-ketohydroximoyl chlorides to form 3-nitrosoimidazo[1,2-a]pyrazines.
Application
2-Aminopyrazine is a synthetic intermediate useful for pharmaceutical synthesis. It is used to synthesize favipiravir and substrate in a four-component synthesis of imidazolidines.
Definition
ChEBI: Aminopyrazine is a member of pyrazines.
Synthesis
General procedure for the synthesis of aminopyrazine from 2-cyanopyrazine: 30 g of 20% sodium hydroxide solution and 100 ml of sodium hypochlorite solution were added to a 500 ml three-necked flask, and 2-cyanopyrazine (21 g, 0.2 mol) was added slowly at room temperature, and the reaction was stirred for 1 hour. Subsequently, the reaction system was warmed up to 50-60°C and the reaction was continued for 4 hours. After completion of the reaction, extraction was carried out with dichloromethane (4 x 200 ml), the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated under reduced pressure to give 15.7 g of white solid product in 82.6% yield.
References
[1] Patent: CN105622526, 2016, A. Location in patent: Paragraph 0020; 0021; 0022
[2] Patent: CN108570011, 2018, A. Location in patent: Paragraph 0012; 0013; 0014
