Synthesis
General method: Catalyst (0.1 mol %) and potassium hydroxide (1 mmol) were dissolved in isopropanol (4 mL). To this solution 2-acetylpyrazine (1 mmol) was added and the mixture was heated to reflux (82 °C). The progress of the reaction was monitored by gas chromatography (GC) periodically during the reaction. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a silica gel or alumina column using a 50% ethyl acetate-hexane mixture as the eluent. The eluate was collected, concentrated and analyzed by gas chromatography (GC) and/or gas chromatography-mass spectrometry (GC-MS).
References
[1] Journal of Organic Chemistry, 1992, vol. 57, # 17, p. 4756 - 4761
[2] Organic Letters, 2005, vol. 7, # 12, p. 2505 - 2508
[3] Bioscience, Biotechnology and Biochemistry, 2011, vol. 75, # 6, p. 1055 - 1060
[4] Organic and Biomolecular Chemistry, 2015, vol. 13, # 6, p. 1768 - 1777
[5] Organic and Biomolecular Chemistry, 2017, vol. 15, # 43, p. 9169 - 9175
